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Multicomponent reaction of aldehydes, amines and oxalacetate analogues leading to biologically attractive pyrrole derivatives

dc.creatorManta S., Kollatos N., Mitsos C., Chatzieffraimidi G.-A., Papanastasiou I., Gallos J.K., Komiotis D.en
dc.date.accessioned2023-01-31T08:56:55Z
dc.date.available2023-01-31T08:56:55Z
dc.date.issued2020
dc.identifier10.2174/1389557520666200103123114
dc.identifier.issn13895575
dc.identifier.urihttp://hdl.handle.net/11615/76291
dc.description.abstractPyrrole is a very important pharmacophoric moiety. It has been widely incorporated into the skeleton of antitumor, anti-inflammatory, antibacterial, antioxidant and antifungal active substances. Access to this key heterocycle by diverse routes is particularly attractive in terms of chemistry, and al-so from the environmental point of view. The present minireview summarizes the reported methods for the preparation of highly substituted pyrrole derivatives based on the one-pot multicomponent reaction of aldehydes, primary amines, and oxalacetate analogues as well as their biology. © 2020 Bentham Science Publishers.en
dc.language.isoenen
dc.sourceMini-Reviews in Medicinal Chemistryen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85085626940&doi=10.2174%2f1389557520666200103123114&partnerID=40&md5=17f375380cd2fdabc93ba4b95a5e0eba
dc.subject1 (4 aminosulfonylphenyl) 5 aryl 4 acyl 3 hydroxy 3 pyrrolin2 one derivativeen
dc.subject1 (4 antipyryl) 5 aryl 4 aroyl 3 pyrrolin 2 one derivativeen
dc.subject1 methyl 5 aryltetrahydropyrrole 2,3 dione derivativeen
dc.subject1,5 diaryl 4 ethoxycarbonyltetrahydropyrrole 2,3 dione derivativeen
dc.subject1,5 diaryl 4 heteroyl 3 hydroxy 3 pyrrolin 2 one derivativeen
dc.subject1,5 diaryltetrahydropyrrole 2,3 dione derivativeen
dc.subject2,3 dioxo 5 (4 halophenyl)pyrrolidine derivativeen
dc.subject2,3 dioxo 5 (hetero)arylpyrrolidine derivativeen
dc.subject3 hydroxy 1,5 dihydro 2h pyrrol 2 one derivativeen
dc.subject3 hydroxy 3 pyrrolin 2 one derivativeen
dc.subject5 aryl 4 acyl (heteroyl) 3 hydroxy 1 (3 ethoxypropyl) 3 pyrrolin 2 one derivativeen
dc.subject5 aryl 4 acyl 1 (n,n dimethylaminoethyl) 3 hydroxy 3 pyrrolin 2 one derivativeen
dc.subject5 aryl 4 acyl 3 hydroxy 1 (2 hydroxyethyl) 3 pyrrolin 2 one derivativeen
dc.subject5 aryl 4 acyl 3 hydroxy 3 pyrrolin 2 one derivativeen
dc.subject5 aryl 4 aroyl 3 hydroxy 1 (4 guanidylsulfonylphenyl) 3 pyrrolin 2 one derivativeen
dc.subject5 aryl 4 aroyl l (2 diethylaminoethyl) 3 hydroxy 3 pyrrolin 2 one derivativeen
dc.subjectaldehyde derivativeen
dc.subjectamineen
dc.subjectdihydrochromeno[2,3 c]pyrrole 3,9 dione derivativeen
dc.subjectoxaloacetic acid derivativeen
dc.subjectpyrrole derivativeen
dc.subjectpyrrolinone derivativeen
dc.subjectunclassified drugen
dc.subjectaldehydeen
dc.subjectamineen
dc.subjectoxaloacetic aciden
dc.subjectpyrrole derivativeen
dc.subjectanalgesic activityen
dc.subjectantibacterial activityen
dc.subjectantileukemic activityen
dc.subjectantimicrobial activityen
dc.subjectantiviral activityen
dc.subjectArticleen
dc.subjectbiological activityen
dc.subjectchemical reactionen
dc.subjectdrug screeningen
dc.subjectdrug structureen
dc.subjectdrug synthesisen
dc.subjecthumanen
dc.subjectmulticomponent reactionen
dc.subjectnonhumanen
dc.subjectone pot synthesisen
dc.subjectstructure activity relationen
dc.subjectchemistryen
dc.subjectdrug developmenten
dc.subjectAldehydesen
dc.subjectAminesen
dc.subjectDrug Discoveryen
dc.subjectOxaloacetic Aciden
dc.subjectPyrrolesen
dc.subjectBentham Science Publishersen
dc.titleMulticomponent reaction of aldehydes, amines and oxalacetate analogues leading to biologically attractive pyrrole derivativesen
dc.typejournalArticleen


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