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Two-stage, school and community-based population screening successfully identifies individuals and families at high-risk for type 2 diabetes: The Feel4Diabetes-study
dc.creator | Manios Y., Mavrogianni C., Lambrinou C.-P., Cardon G., Lindström J., Iotova V., Tankova T., Civeira F., Kivelä J., Jancsó Z., Shadid S., Tsochev K., Mateo-Gallego R., Radó S., Dafoulas G., Makrilakis K., Androutsos O. | en |
dc.date.accessioned | 2023-01-31T08:56:49Z | |
dc.date.available | 2023-01-31T08:56:49Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.1186/s12902-019-0478-9 | |
dc.identifier.issn | 14726823 | |
dc.identifier.uri | http://hdl.handle.net/11615/76274 | |
dc.description.abstract | Background: The implementation of population screening and early prevention strategies targeting individuals at high-risk for type 2 diabetes (T2D) seems to be a public health priority. The current work aimed to describe the screening procedure applied in the Feel4Diabetes-study and examine its effectiveness in identifying individuals and families at high risk, primarily for T2D and secondarily for hypertension, among vulnerable populations in low to middle-income countries (LMICs) and high-income countries (HICs) across Europe. Methods: A two-stage screening procedure, using primary schools as the entry-point to the community, was applied in low socioeconomic status (SES) regions in LMICs (Bulgaria-Hungary), HICs (Belgium-Finland) and HICs under austerity measures (Greece-Spain). During the first-stage screening via the school-setting, a total of 20,501 parents (mothers and/or fathers) of schoolchildren from 11,396 families completed the Finnish Diabetes Risk Score (FINDRISC) questionnaire, while their children underwent anthropometric measurements in the school setting. Parents from the identified "high-risk families" (n = 4484) were invited to participate in the second-stage screening, including the measurement of fasting plasma glucose (FPG) and blood pressure (BP). In total, 3153 parents participated in the second-stage screening (mean age 41.1 ± 5.6 years, 65.8% females). Results: Among parents who attended the second-stage screening, the prevalence of prediabetes (as defined by impaired fasting glucose; FPG 100-125 mg/dl) and T2D (FPG > 126 mg/dl) was 23.2 and 3.0% respectively, and it was found to be higher in the higher FINDRISC categories. The percentage of undiagnosed T2D among the participants identified with T2D was 53.5%. The prevalence of high normal BP (systolic BP 130-139 mmHg and/or diastolic BP 85-89 mmHg) and hypertension (systolic BP ≥ 140 mmHg and/or diastolic BP ≥ 90 mmHg) was 14 and 18.6% respectively, which was also higher in the higher FINDRISC categories. The percentage of cases not receiving antihypertensive treatment among the participants identified with hypertension was 80.3%. Conclusion: The findings of the current study indicate that the two-stage school and community-based screening procedure followed, effectively identified high-risk individuals and families in vulnerable populations across Europe. This approach could be potentially scalable and sustainable and support initiatives for the early prevention of T2D and hypertension. Trial registration: The Feel4Diabetes-intervention is registered at http://clinicaltrials.gov/(NCT02393872; date of trial registration: March 20, 2015). © 2020 The Author(s). | en |
dc.language.iso | en | en |
dc.source | BMC Endocrine Disorders | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081915592&doi=10.1186%2fs12902-019-0478-9&partnerID=40&md5=912f6c3e03ecf90be1d04f0f00f417fd | |
dc.subject | glucose | en |
dc.subject | adult | en |
dc.subject | anthropometry | en |
dc.subject | antihypertensive therapy | en |
dc.subject | Article | en |
dc.subject | blood pressure measurement | en |
dc.subject | child | en |
dc.subject | controlled study | en |
dc.subject | diagnostic error | en |
dc.subject | diastolic blood pressure | en |
dc.subject | disease control | en |
dc.subject | Europe | en |
dc.subject | fasting | en |
dc.subject | female | en |
dc.subject | Finnish Diabetes Risk Score | en |
dc.subject | glucose blood level | en |
dc.subject | high income country | en |
dc.subject | high risk population | en |
dc.subject | human | en |
dc.subject | hypertension | en |
dc.subject | impaired glucose tolerance | en |
dc.subject | low income country | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | mass screening | en |
dc.subject | middle income country | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | prevalence | en |
dc.subject | primary school | en |
dc.subject | public health service | en |
dc.subject | school child | en |
dc.subject | social status | en |
dc.subject | systolic blood pressure | en |
dc.subject | vulnerable population | en |
dc.subject | clinical trial | en |
dc.subject | community care | en |
dc.subject | demography | en |
dc.subject | family | en |
dc.subject | feasibility study | en |
dc.subject | impaired glucose tolerance | en |
dc.subject | middle aged | en |
dc.subject | multicenter study | en |
dc.subject | non insulin dependent diabetes mellitus | en |
dc.subject | organization and management | en |
dc.subject | preventive health service | en |
dc.subject | procedures | en |
dc.subject | program evaluation | en |
dc.subject | randomized controlled trial | en |
dc.subject | risk factor | en |
dc.subject | school | en |
dc.subject | school health service | en |
dc.subject | Adult | en |
dc.subject | Child | en |
dc.subject | Community Networks | en |
dc.subject | Diabetes Mellitus, Type 2 | en |
dc.subject | Europe | en |
dc.subject | Family | en |
dc.subject | Feasibility Studies | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Implementation Science | en |
dc.subject | Male | en |
dc.subject | Mass Screening | en |
dc.subject | Middle Aged | en |
dc.subject | Prediabetic State | en |
dc.subject | Prevalence | en |
dc.subject | Preventive Health Services | en |
dc.subject | Program Evaluation | en |
dc.subject | Residence Characteristics | en |
dc.subject | Risk Factors | en |
dc.subject | School Health Services | en |
dc.subject | Schools | en |
dc.subject | Vulnerable Populations | en |
dc.subject | BioMed Central Ltd. | en |
dc.title | Two-stage, school and community-based population screening successfully identifies individuals and families at high-risk for type 2 diabetes: The Feel4Diabetes-study | en |
dc.type | journalArticle | en |
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