dc.creator | Magouliotis D.E., Tasiopoulou V.S., Dimas K., Sakellaridis N., Svokos K.A., Svokos A.A., Zacharoulis D. | en |
dc.date.accessioned | 2023-01-31T08:55:46Z | |
dc.date.available | 2023-01-31T08:55:46Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1016/j.pan.2019.02.006 | |
dc.identifier.issn | 14243903 | |
dc.identifier.uri | http://hdl.handle.net/11615/76091 | |
dc.description.abstract | Background: This study aimed to assess the differential gene expression of aquaporin (AQP) gene family interactome in pancreatic ductal adenocarcinoma (PDAC) using data mining techniques to identify novel candidate genes intervening in the pathogenicity of PDAC. Method: Transcriptome data mining techniques were used in order to construct the interactome of the AQP gene family and to determine which genes members are differentially expressed in PDAC as compared to controls. The same techniques were used in order to evaluate the potential prognostic role of the differentially expressed genes. Results: Transcriptome microarray data of four GEO datasets were incorporated, including 142 primary tumor samples and 104 normal pancreatic tissue samples. Twenty differentially expressed genes were identified, of which nineteen were downregulated and one up-regulated. A molecular panel of four genes (Aquaporin 7 – AQP7; Archain 1 – ARCN1; Exocyst Complex Component 3 – EXOC3; Coatomer Protein Complex Subunit Epsilon – COPE) were identified as potential prognostic markers associated with overall survival. Conclusion: These outcomes should be further assessed in vitro in order to fully understand the role of these genes in the pathophysiological mechanism of PDAC. © 2019 IAP and EPC | en |
dc.language.iso | en | en |
dc.source | Pancreatology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062015923&doi=10.1016%2fj.pan.2019.02.006&partnerID=40&md5=467d80a9a9566f82baf40c39d17e6fdb | |
dc.subject | aquaporin | en |
dc.subject | aquaporin 1 | en |
dc.subject | aquaporin 10 | en |
dc.subject | aquaporin 11 | en |
dc.subject | aquaporin 12a | en |
dc.subject | aquaporin 12b | en |
dc.subject | aquaporin 2 | en |
dc.subject | aquaporin 3 | en |
dc.subject | aquaporin 4 | en |
dc.subject | aquaporin 6 | en |
dc.subject | aquaporin 7 | en |
dc.subject | aquaporin 8 | en |
dc.subject | archain 1 | en |
dc.subject | coatomer protein | en |
dc.subject | coatomer protein complex subunit alpha | en |
dc.subject | coatomer protein complex subunit beta 1 | en |
dc.subject | coatomer protein complex subunit beta 2 | en |
dc.subject | coatomer protein complex subunit epsilon | en |
dc.subject | coatomer protein complex subunit gamma 1 | en |
dc.subject | coatomer protein complex subunit gamma 2 | en |
dc.subject | exocyst complex component 3 | en |
dc.subject | rh associated glycoprotein | en |
dc.subject | ribonucleotide reductase regulatory tp53 inducible subunit m2b | en |
dc.subject | sodium glucose cotransporter 1 | en |
dc.subject | transcriptome | en |
dc.subject | tumor marker | en |
dc.subject | unclassified drug | en |
dc.subject | aquaporin | en |
dc.subject | Article | en |
dc.subject | cancer prognosis | en |
dc.subject | cancer survival | en |
dc.subject | controlled study | en |
dc.subject | down regulation | en |
dc.subject | gene expression | en |
dc.subject | human | en |
dc.subject | human tissue | en |
dc.subject | major clinical study | en |
dc.subject | multigene family | en |
dc.subject | overall survival | en |
dc.subject | pancreas adenocarcinoma | en |
dc.subject | pancreas tissue | en |
dc.subject | pathogenicity | en |
dc.subject | priority journal | en |
dc.subject | transcriptomics | en |
dc.subject | upregulation | en |
dc.subject | adenocarcinoma | en |
dc.subject | gene expression profiling | en |
dc.subject | gene expression regulation | en |
dc.subject | genetic database | en |
dc.subject | genetics | en |
dc.subject | metabolism | en |
dc.subject | multigene family | en |
dc.subject | pancreas carcinoma | en |
dc.subject | pancreas tumor | en |
dc.subject | pathology | en |
dc.subject | physiology | en |
dc.subject | protein microarray | en |
dc.subject | Adenocarcinoma | en |
dc.subject | Aquaporins | en |
dc.subject | Carcinoma, Pancreatic Ductal | en |
dc.subject | Databases, Genetic | en |
dc.subject | Down-Regulation | en |
dc.subject | Gene Expression Profiling | en |
dc.subject | Gene Expression Regulation, Neoplastic | en |
dc.subject | Humans | en |
dc.subject | Multigene Family | en |
dc.subject | Pancreatic Neoplasms | en |
dc.subject | Protein Array Analysis | en |
dc.subject | Up-Regulation | en |
dc.subject | Elsevier B.V. | en |
dc.title | Transcriptomic analysis of the Aquaporin (AQP) gene family interactome identifies a molecular panel of four prognostic markers in patients with pancreatic ductal adenocarcinoma | en |
dc.type | journalArticle | en |