Mostra i principali dati dell'item
Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation
dc.creator | Lu X., Liu M., Dong H., Miao J., Stagos D., Liu M. | en |
dc.date.accessioned | 2023-01-31T08:55:30Z | |
dc.date.available | 2023-01-31T08:55:30Z | |
dc.date.issued | 2022 | |
dc.identifier | 10.1016/j.fct.2022.112813 | |
dc.identifier.issn | 02786915 | |
dc.identifier.uri | http://hdl.handle.net/11615/76024 | |
dc.description.abstract | Diabetic skin ulcer is one of the most common complications in patients suffering diabetes mellitus. Xanthohumol (XN), a hop-derived prenylated dietary flavonoid, has multiple health beneficial bioactivities. In the present study, we reported XN alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation. In vitro, XN attenuated hydrogen peroxide (H2O2)-induced cytotoxicity, ROS production, cell apoptosis, as well as high glucose-induced cell damage. Mechanistic studies further demonstrated that XN could stabilize nuclear factor erythroid 2-related factor 2 (Nrf2) and promote its nuclear translocation, which was associated with AMPKα activation and covalent modification of Keap1 by XN. In vivo, XN increased Nrf2 expression and accelerated diabetic wound healing. Our study revealed a novel function of XN in diabetic wound healing as well as the underlying molecular mechanisms, suggesting XN is a promising lead compound and a potential food and/or drug candidate for the treatment of diabetic skin ulcers. © 2022 Elsevier Ltd | en |
dc.language.iso | en | en |
dc.source | Food and Chemical Toxicology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122617192&doi=10.1016%2fj.fct.2022.112813&partnerID=40&md5=9d6eafe0080f5e91dc6c5cc38fd99b31 | |
dc.subject | glutathione | en |
dc.subject | glutathione disulfide | en |
dc.subject | hydrogen peroxide | en |
dc.subject | hydroxymethylglutaryl coenzyme A reductase kinase | en |
dc.subject | kelch like ECH associated protein 1 | en |
dc.subject | malonaldehyde | en |
dc.subject | reactive oxygen metabolite | en |
dc.subject | superoxide dismutase | en |
dc.subject | transcription factor Nrf2 | en |
dc.subject | xanthohumol | en |
dc.subject | flavonoid | en |
dc.subject | kelch like ECH associated protein 1 | en |
dc.subject | propiophenone derivative | en |
dc.subject | transcription factor Nrf2 | en |
dc.subject | xanthohumol | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | animal tissue | en |
dc.subject | apoptosis | en |
dc.subject | Article | en |
dc.subject | cell damage | en |
dc.subject | controlled study | en |
dc.subject | cytotoxicity | en |
dc.subject | diabetic wound | en |
dc.subject | enzyme activation | en |
dc.subject | HaCat cell line | en |
dc.subject | histopathology | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | immunofluorescence | en |
dc.subject | immunoprecipitation | en |
dc.subject | in vitro study | en |
dc.subject | MTT assay | en |
dc.subject | nonhuman | en |
dc.subject | nucleocytoplasmic transport | en |
dc.subject | oxidation | en |
dc.subject | polyacrylamide gel electrophoresis | en |
dc.subject | protein degradation | en |
dc.subject | protein expression | en |
dc.subject | protein synthesis | en |
dc.subject | Western blotting | en |
dc.subject | wound healing | en |
dc.subject | animal | en |
dc.subject | chemistry | en |
dc.subject | diabetic complication | en |
dc.subject | drug effect | en |
dc.subject | genetics | en |
dc.subject | male | en |
dc.subject | metabolism | en |
dc.subject | oxidative stress | en |
dc.subject | pathophysiology | en |
dc.subject | prenylation | en |
dc.subject | rat | en |
dc.subject | skin ulcer | en |
dc.subject | Sprague Dawley rat | en |
dc.subject | wound healing | en |
dc.subject | Animals | en |
dc.subject | Diabetes Complications | en |
dc.subject | Flavonoids | en |
dc.subject | Humans | en |
dc.subject | Kelch-Like ECH-Associated Protein 1 | en |
dc.subject | Male | en |
dc.subject | NF-E2-Related Factor 2 | en |
dc.subject | Oxidative Stress | en |
dc.subject | Prenylation | en |
dc.subject | Propiophenones | en |
dc.subject | Rats | en |
dc.subject | Rats, Sprague-Dawley | en |
dc.subject | Skin Ulcer | en |
dc.subject | Wound Healing | en |
dc.subject | Elsevier Ltd | en |
dc.title | Dietary prenylated flavonoid xanthohumol alleviates oxidative damage and accelerates diabetic wound healing via Nrf2 activation | en |
dc.type | journalArticle | en |
Files in questo item
Files | Dimensione | Formato | Mostra |
---|---|---|---|
Nessun files in questo item. |