dc.creator | Liaskos C., Rentouli S., Simopoulou T., Gkoutzourelas A., Norman G.L., Brotis A., Alexiou I., Katsiari C., Bogdanos D.P., Sakkas L.I. | en |
dc.date.accessioned | 2023-01-31T08:55:06Z | |
dc.date.available | 2023-01-31T08:55:06Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1111/bjd.17886 | |
dc.identifier.issn | 00070963 | |
dc.identifier.uri | http://hdl.handle.net/11615/75908 | |
dc.description.abstract | Background: Anti-C1q autoantibodies (autoAbs) are associated with systemic lupus erythematosus (SLE), but their presence in other rheumatic diseases has not been adequately investigated. Objectives: We aimed to assess anti-C1q autoAbs and circulating immune complexes (CICs) in systemic sclerosis (SSc). Methods: In total 124 patients with SSc were studied; 106 were female and the median age was 59·4 years (range 25–81·4). Overall 75 (60·5%) had limited cutaneous SSc and 49 (39·5%) had diffuse cutaneous SSc. Also included were 25 patients with Sjögren syndrome (SjS), 29 with rheumatoid arthritis (RA), 38 with SLE and 53 healthy controls. Enzyme-linked immunosorbent assays with high- and low-salt buffers were used to measure anti-C1q antibodies and CICs. The former allows only anti-C1q antibody binding to C1q and the latter also allows IgG Fc to bind to C1q. Results: Anti-C1q antibodies were present in 20 of 124 (16·1%) patients with SSc: five had high levels (> 80 RU mL−1) and 10 (50%) had moderate levels (40–80 RU mL−1). Anti-C1q antibodies were also present in one of 25 (4%) patients with SjS, one of 29 (3%) with RA (P < 0·05 for both) and three of 53 (6%) healthy controls (P < 0·01). Anti-C1q antibodies were detected in 13 of 38 (34%) patients with SLEs. Anti-C1q antibodies were more frequent in male than female patients with SSc (P = 0·005); this association remained after multivariate regression analysis. Anti-C1q antibody level was the most important factor in predicting the presence of pulmonary fibrosis, and the second most important in predicting pulmonary arterial hypertension. Fourteen patients with SSc (11·3%) had CICs. Conclusions: Anti-C1q autoAbs were frequently detected in patients with SSc, and their high levels predict the co-occurrence of pulmonary fibrosis or pulmonary arterial hypertension. © 2019 British Association of Dermatologists | en |
dc.language.iso | en | en |
dc.source | British Journal of Dermatology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85065286563&doi=10.1111%2fbjd.17886&partnerID=40&md5=30d0dda76089e8f841e5404aa436db26 | |
dc.subject | complement component C1q antibody | en |
dc.subject | autoantibody | en |
dc.subject | autoantigen | en |
dc.subject | complement component C1q | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | antibody blood level | en |
dc.subject | antigen antibody complex | en |
dc.subject | Article | en |
dc.subject | disease association | en |
dc.subject | enzyme linked immunosorbent assay | en |
dc.subject | female | en |
dc.subject | finger ulcer | en |
dc.subject | human | en |
dc.subject | lung fibrosis | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | priority journal | en |
dc.subject | pulmonary hypertension | en |
dc.subject | rheumatoid arthritis | en |
dc.subject | systemic sclerosis | en |
dc.subject | very elderly | en |
dc.subject | blood | en |
dc.subject | cohort analysis | en |
dc.subject | complication | en |
dc.subject | diagnostic imaging | en |
dc.subject | immunology | en |
dc.subject | lung | en |
dc.subject | lung fibrosis | en |
dc.subject | middle aged | en |
dc.subject | normal human | en |
dc.subject | pathology | en |
dc.subject | sex factor | en |
dc.subject | systemic sclerosis | en |
dc.subject | x-ray computed tomography | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Autoantibodies | en |
dc.subject | Autoantigens | en |
dc.subject | Cohort Studies | en |
dc.subject | Complement C1q | en |
dc.subject | Female | en |
dc.subject | Healthy Volunteers | en |
dc.subject | Humans | en |
dc.subject | Lung | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Pulmonary Fibrosis | en |
dc.subject | Scleroderma, Systemic | en |
dc.subject | Sex Factors | en |
dc.subject | Tomography, X-Ray Computed | en |
dc.subject | Blackwell Publishing Ltd | en |
dc.title | Anti-C1q autoantibodies are frequently detected in patients with systemic sclerosis associated with pulmonary fibrosis | en |
dc.type | journalArticle | en |