Changes of serum sclerostin and Dickkopf-1 levels during the menstrual cycle. A pilot study
dc.creator | Liakou C.G., Mastorakos G., Makris K., Fatouros I.G., Avloniti A., Marketos H., Antoniou J.D., Galanos A., Dontas I., Rizos D., Tournis S. | en |
dc.date.accessioned | 2023-01-31T08:50:26Z | |
dc.date.available | 2023-01-31T08:50:26Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1007/s12020-016-1056-9 | |
dc.identifier.issn | 1355008X | |
dc.identifier.uri | http://hdl.handle.net/11615/75821 | |
dc.description.abstract | Studies in postmenopausal women have identified sclerostin as a strong candidate for mediating estrogen effects on the skeleton. The effects of estradiol on sclerostin and Dickkopf-1 in younger women remain unclear. The main purpose of this study is to investigate the impact of estradiol and gonadotrophins fluctuations during the menstrual cycle on circulating sclerostin and Dickkopf-1 levels and the possible relationship of sclerostin and Dickkopf-1 with changes in N-terminal propeptide of type 1 collagen and C-telopeptide of collagen cross-links. Fourteen healthy premenopausal Caucasian women, with regular menses, aged 33.6 ± 4.5 years participated. After the first day of menstruation and every-other-day up to the next menses, fasting serum estradiol, luteinizing hormone, follicle-stimulating hormone, sclerostin, Dickkopf-1, N-terminal propeptide of type 1 collagen, and C-telopeptide of collagen cross-links levels were measured in peripheral blood. Participants completed dietary questionnaires and the International physical activity questionnaire during the cycle. Neither sclerostin nor Dickkopf-1 levels changed significantly across the menstrual cycle (p = 0.18 and p = 0.39, respectively), while N-terminal propeptide of type 1 collagen and C-telopeptide of collagen cross-links levels presented cyclic variation (p < 0.001 and p = 0.004, respectively). Baseline sclerostin (29.23 ± 10.62 pmol/L) positively correlated with N-terminal propeptide of type 1 collagen (r = 0.71, p < 0.01) and C-telopeptide of collagen cross-links (r = 0.63, p < 0.05), while Dickkopf-1 (4.82 ± 2.23 pmol/L) correlated positively with N-terminal propeptide of type 1 collagen (r = 0.56, p < 0.05). Mid-cycle E2 levels presented significant negative association with the percent decrease of C-telopeptide of collagen cross-links at all-time points during the luteal period (r = −0.60 to −0.68, p < 0.05–0.01). Circulating sclerostin and Dickkopf-1 levels do not change across the menstrual cycle and do not demonstrate any relationship with estradiol in premenopausal women. Further investigation is needed concerning the role of sclerostin and Dickkopf-1 on bone turnover in young estrogen-sufficient women. © 2016, Springer Science+Business Media New York. | en |
dc.language.iso | en | en |
dc.source | Endocrine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84986264892&doi=10.1007%2fs12020-016-1056-9&partnerID=40&md5=f02b7c130c969b67402e3272d10d5f9e | |
dc.subject | amino terminal telopeptide | en |
dc.subject | carboxy terminal telopeptide | en |
dc.subject | dickkopf 1 protein | en |
dc.subject | estradiol | en |
dc.subject | follitropin | en |
dc.subject | gonadotropin | en |
dc.subject | luteinizing hormone | en |
dc.subject | sclerostin | en |
dc.subject | bone morphogenetic protein | en |
dc.subject | collagen type 1 | en |
dc.subject | DKK1 protein, human | en |
dc.subject | genetic marker | en |
dc.subject | peptide | en |
dc.subject | signal peptide | en |
dc.subject | SOST protein, human | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | Caucasian | en |
dc.subject | dietary intake | en |
dc.subject | estradiol blood level | en |
dc.subject | female | en |
dc.subject | follitropin blood level | en |
dc.subject | human | en |
dc.subject | luteinizing hormone blood level | en |
dc.subject | menstrual cycle | en |
dc.subject | normal human | en |
dc.subject | physical activity | en |
dc.subject | pilot study | en |
dc.subject | premenopause | en |
dc.subject | priority journal | en |
dc.subject | protein blood level | en |
dc.subject | protein cross linking | en |
dc.subject | questionnaire | en |
dc.subject | blood | en |
dc.subject | genetic marker | en |
dc.subject | menstrual cycle | en |
dc.subject | young adult | en |
dc.subject | Adult | en |
dc.subject | Bone Morphogenetic Proteins | en |
dc.subject | Collagen Type I | en |
dc.subject | Female | en |
dc.subject | Genetic Markers | en |
dc.subject | Humans | en |
dc.subject | Intercellular Signaling Peptides and Proteins | en |
dc.subject | Menstrual Cycle | en |
dc.subject | Peptides | en |
dc.subject | Pilot Projects | en |
dc.subject | Young Adult | en |
dc.subject | Humana Press Inc. | en |
dc.title | Changes of serum sclerostin and Dickkopf-1 levels during the menstrual cycle. A pilot study | en |
dc.type | journalArticle | en |
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