dc.creator | Kyriakopoulou Z., Amoutzias G.D., Dimitriou T.G., Tsakogiannis D., Mossialos D., Markoulatos P. | en |
dc.date.accessioned | 2023-01-31T08:47:43Z | |
dc.date.available | 2023-01-31T08:47:43Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.1007/s00705-017-3600-1 | |
dc.identifier.issn | 03048608 | |
dc.identifier.uri | http://hdl.handle.net/11615/75575 | |
dc.description.abstract | Recombination has been recognized as a major mechanism of evolution in enteroviruses. The Echovirus 30 (E-30) strain Gior was sequenced and phylogenetically compared to all available E-30 sequences to detect recombination events between the 5΄UTR and VP1 genomic regions. The comparison of phylogenetic trees of the 5΄UTR and VP1 revealed incongruences concerning strains, lineages and sub-lineages. Comparative analysis of 62 E-30 sub-genomic sequences revealed six different recombination events that almost all occurred in the same region, having a start point in the 3΄end of the 5΄ UTR and end point in VP4. The only exception was the sub-lineage of Gior for which both borders of recombination were located in the 5΄UTR. These results describe for the first time recombination events in this region in circulating EV-B strains, revealing the exact points of these recombination events, highlighting the impact of such events on the evolution and epidemiology of enteroviruses. © 2017, Springer-Verlag GmbH Austria. | en |
dc.language.iso | en | en |
dc.source | Archives of Virology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041774730&doi=10.1007%2fs00705-017-3600-1&partnerID=40&md5=681c13f5979da03d73ca4ada00e0b2ea | |
dc.subject | viral protein | en |
dc.subject | virus RNA | en |
dc.subject | 5' untranslated region | en |
dc.subject | classification | en |
dc.subject | Echovirus infection | en |
dc.subject | Enterovirus B | en |
dc.subject | genetic recombination | en |
dc.subject | genetics | en |
dc.subject | human | en |
dc.subject | isolation and purification | en |
dc.subject | metabolism | en |
dc.subject | molecular evolution | en |
dc.subject | phylogeny | en |
dc.subject | physiology | en |
dc.subject | serotype | en |
dc.subject | virology | en |
dc.subject | virus genome | en |
dc.subject | 5' Untranslated Regions | en |
dc.subject | Echovirus Infections | en |
dc.subject | Enterovirus B, Human | en |
dc.subject | Evolution, Molecular | en |
dc.subject | Genome, Viral | en |
dc.subject | Humans | en |
dc.subject | Phylogeny | en |
dc.subject | Recombination, Genetic | en |
dc.subject | RNA, Viral | en |
dc.subject | Serogroup | en |
dc.subject | Viral Proteins | en |
dc.subject | Springer-Verlag Wien | en |
dc.title | Intra- and inter-serotypic recombinations in the 5΄ UTR-VP4 region of Echovirus 30 strains | en |
dc.type | journalArticle | en |