dc.creator | Krasanakis T., Nikolouzakis T.K., Sgantzos M., Mariolis-Sapsakos T., Souglakos J., Spandidos D.A., Tsitsimpikou C., Tsatsakis A., Tsiaoussis J. | en |
dc.date.accessioned | 2023-01-31T08:47:02Z | |
dc.date.available | 2023-01-31T08:47:02Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.3892/or.2019.7351 | |
dc.identifier.issn | 1021335X | |
dc.identifier.uri | http://hdl.handle.net/11615/75506 | |
dc.description.abstract | Colorectal cancer (CRC) is one of the four leading causes of cancer-related mortality worldwide. Even though over the past few decades the global scientific community has made tremendous efforts to understand this entity, many questions remain to be raised on this issue and even more to be answered. Epidemiological findings have unveiled numerous environmental and genetic risk factors, each one contributing to a certain degree to the final account of new CRC cases. Moreover, different trends have been revealed regarding the age of onset of CRC between the two sexes. That, in addition to newly introduced therapeutic approaches for various diseases based on androgens, anti-androgens and anabolic hormones has raised some concerns regarding their possible carcinogenic effects or their synergistic potential with other substances/risk factors, predisposing the individual to CRC. Notably, despite the intense research on experimental settings and population studies, the conclusions regarding the majority of anabolic substances are ambiguous. Some of these indicate the carcinogenic properties of testosterone, dihydrotestosterone (DHT), growth hormone and insulin-like growth factor (IGF) and others, demonstrating their neutral nature or even their protective one, as in the case of vitamin D. Thus, the synergistic nature of anabolic substances with other CRC risk factors (such as type 2 diabetes mellitus, metabolic syndrome and smoking) has emerged, suggesting a more holistic approach. © 2019 Spandidos Publications. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Oncology Reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85074534320&doi=10.3892%2for.2019.7351&partnerID=40&md5=fc39add38361f7c4abbcbc9d74e839cd | |
dc.subject | anabolic agent | en |
dc.subject | androgen | en |
dc.subject | androgen receptor | en |
dc.subject | growth hormone | en |
dc.subject | insulin | en |
dc.subject | insulin receptor | en |
dc.subject | prasterone | en |
dc.subject | protein arginine methyltransferase | en |
dc.subject | protein co activator associated arginine methyltransferase 1 | en |
dc.subject | protein epithelial insulin receptor | en |
dc.subject | protein vascular insulin receptor | en |
dc.subject | selective androgen receptor modulator | en |
dc.subject | somatomedin binding protein | en |
dc.subject | somatomedin receptor | en |
dc.subject | testosterone | en |
dc.subject | unclassified drug | en |
dc.subject | vitamin D | en |
dc.subject | anabolic agent | en |
dc.subject | androgen blood level | en |
dc.subject | cancer growth | en |
dc.subject | carcinogenesis | en |
dc.subject | colorectal carcinoma | en |
dc.subject | disease association | en |
dc.subject | gene function | en |
dc.subject | human | en |
dc.subject | nonhuman | en |
dc.subject | priority journal | en |
dc.subject | protein expression | en |
dc.subject | Review | en |
dc.subject | animal | en |
dc.subject | carcinogenesis | en |
dc.subject | colorectal tumor | en |
dc.subject | drug effect | en |
dc.subject | pathology | en |
dc.subject | risk factor | en |
dc.subject | Anabolic Agents | en |
dc.subject | Animals | en |
dc.subject | Carcinogenesis | en |
dc.subject | Colorectal Neoplasms | en |
dc.subject | Humans | en |
dc.subject | Risk Factors | en |
dc.subject | Spandidos Publications | en |
dc.title | Role of anabolic agents in colorectal carcinogenesis: Myths and realities (Review) | en |
dc.type | other | en |