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Clinical Significance of Circulating Osteopontin Levels in Patients With Lung Cancer and Correlation With VEGF and MMP-9

dc.creatorKerenidi T., Kazakou A.P., Lada M., Tsilioni I., Daniil Z., Gourgoulianis K.I.en
dc.date.accessioned2023-01-31T08:43:15Z
dc.date.available2023-01-31T08:43:15Z
dc.date.issued2016
dc.identifier10.1080/07357907.2016.1223301
dc.identifier.issn07357907
dc.identifier.urihttp://hdl.handle.net/11615/74866
dc.description.abstractOsteopontin (OPN) is a multifunctional cytokine involved in carcinogenesis. Serum levels of OPN, vascular endothelial growth factor (VEGF), and matrix metalloproteinase-9 (MMP-9) were measured by ELISA in 90 lung cancer patients. OPN levels were elevated in patients compared to controls (p <.0001). Smokers, patients with worse performance status, and weight loss exhibited higher OPN levels (p =.0012,.00036, and.0003, respectively). Increased OPN levels were associated with worse survival (p =.0018). Finally, OPN levels were positively correlated with both VEGF (p =.0008) and MMP-9 (p <.0001). OPN might serve as a prognostic biomarker, and the positive correlation between OPN and both VEGF and MMP-9 could implicate new insights in tumor angiogenesis. © 2016 Taylor & Francis Group, LLC.en
dc.language.isoenen
dc.sourceCancer Investigationen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84987654721&doi=10.1080%2f07357907.2016.1223301&partnerID=40&md5=4517ae97b02ba0e69dce4db662c69fb2
dc.subjectgelatinase Ben
dc.subjectosteopontinen
dc.subjectvasculotropinen
dc.subjectgelatinase Ben
dc.subjectosteopontinen
dc.subjecttumor markeren
dc.subjectvasculotropin Aen
dc.subjectadulten
dc.subjectageden
dc.subjectArticleen
dc.subjectcancer patienten
dc.subjectcancer prognosisen
dc.subjectcancer survivalen
dc.subjectcohort analysisen
dc.subjectcomparative studyen
dc.subjectcontrolled studyen
dc.subjectenzyme linked immunosorbent assayen
dc.subjectfemaleen
dc.subjecthumanen
dc.subjectlung canceren
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectmiddle ageden
dc.subjectnon small cell lung canceren
dc.subjectoverall survivalen
dc.subjectpriority journalen
dc.subjectprospective studyen
dc.subjectprotein blood levelen
dc.subjectsmall cell lung canceren
dc.subjectsmokingen
dc.subjectweight reductionen
dc.subjectbiopsyen
dc.subjectblooden
dc.subjectcancer gradingen
dc.subjectcancer stagingen
dc.subjectcase control studyen
dc.subjectLung Neoplasmsen
dc.subjectmortalityen
dc.subjectneovascularization (pathology)en
dc.subjectprognosisen
dc.subjectAgeden
dc.subjectBiomarkers, Tumoren
dc.subjectBiopsyen
dc.subjectCase-Control Studiesen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectLung Neoplasmsen
dc.subjectMaleen
dc.subjectMatrix Metalloproteinase 9en
dc.subjectMiddle Ageden
dc.subjectNeoplasm Gradingen
dc.subjectNeoplasm Stagingen
dc.subjectNeovascularization, Pathologicen
dc.subjectOsteopontinen
dc.subjectPrognosisen
dc.subjectVascular Endothelial Growth Factor Aen
dc.subjectTaylor and Francis Ltden
dc.titleClinical Significance of Circulating Osteopontin Levels in Patients With Lung Cancer and Correlation With VEGF and MMP-9en
dc.typejournalArticleen


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