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Effects of sheep/goat whey protein dietary supplementation on the redox status of rats
dc.creator | Kerasioti E., Stagos D., Tsatsakis A.M., Spandidos D.A., Taitzoglou I., Kouretas D. | en |
dc.date.accessioned | 2023-01-31T08:43:14Z | |
dc.date.available | 2023-01-31T08:43:14Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.3892/mmr.2018.8622 | |
dc.identifier.issn | 17912997 | |
dc.identifier.uri | http://hdl.handle.net/11615/74860 | |
dc.description.abstract | The purpose of the present study is to estimate the effects of sheep/goat whey protein dietary supplementation on the redox status of blood and tissues of rats. Twelve male Wistar rats were divided into the control group (standard commercial diet) and whey group [standard commercial diet + sheep/goat whey protein (1 g kg b.w/day)] (6 rats/group). The animals were maintainted on their respective diet for 28 days. At the end of the experimental period, reduced glutathione, catalase activity, total antioxidant capacity, thiobarbituric reactive substances, protein carbonyls and the decomposition rate of H 2O 2 were measured in blood and tissues of rats. According to the results, the rats fed with the sheep/goat whey protein exhibited improved antioxidant status and decreased free radical-induced toxic effects on lipids and proteins. Specifically, in blood, GSH and CAT levels were significantly increased while TBARS and protein carbonyl levels were significantly decreased compared to the control group. Regarding the effects on tissues, it was observed that GSH levels were significantly increased in small intestine, quadriceps muscle, pancreas and lung tissue compared to the control group. The decomposition rate of H 2O 2 was significantly decreased in liver, brain and quadriceps muscle, but was significantly increased in spleen tissue compared to the control group. TBARS levels were significantly decreased in liver, brain, quadriceps muscle, pancreas, lung and spleen tissue compared to the control group. Finally, protein carbonyl levels were significantly decreased in brain, small intestine, kidney, pancreas and spleen tissue compared to the control group. Thus, the present findings show the beneficial effects of sheep/goat whey protein, a by-product of cheese manufacturing, on the redox status in an in vivo model. © 2018 Kashyap. | en |
dc.language.iso | en | en |
dc.source | Molecular Medicine Reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85043266947&doi=10.3892%2fmmr.2018.8622&partnerID=40&md5=a2fba2d692d9c28974f9f4f7fcc20c13 | |
dc.subject | carbonyl derivative | en |
dc.subject | catalase | en |
dc.subject | glutathione | en |
dc.subject | hydrogen peroxide | en |
dc.subject | sheep goat whey protein | en |
dc.subject | thiobarbituric acid reactive substance | en |
dc.subject | unclassified drug | en |
dc.subject | whey protein | en |
dc.subject | biological marker | en |
dc.subject | reactive oxygen metabolite | en |
dc.subject | animal cell | en |
dc.subject | animal experiment | en |
dc.subject | animal tissue | en |
dc.subject | antioxidant activity | en |
dc.subject | antioxidant assay | en |
dc.subject | Article | en |
dc.subject | brain | en |
dc.subject | controlled study | en |
dc.subject | decomposition | en |
dc.subject | diet supplementation | en |
dc.subject | enzyme activity | en |
dc.subject | hemolysate | en |
dc.subject | in vivo study | en |
dc.subject | liver | en |
dc.subject | lung parenchyma | en |
dc.subject | male | en |
dc.subject | nonhuman | en |
dc.subject | oxidative stress | en |
dc.subject | quadriceps femoris muscle | en |
dc.subject | rat | en |
dc.subject | small intestine | en |
dc.subject | spleen tissue | en |
dc.subject | animal | en |
dc.subject | animal food | en |
dc.subject | biological model | en |
dc.subject | dietary supplement | en |
dc.subject | goat | en |
dc.subject | lipid peroxidation | en |
dc.subject | metabolism | en |
dc.subject | oxidation reduction reaction | en |
dc.subject | sheep | en |
dc.subject | Animal Feed | en |
dc.subject | Animals | en |
dc.subject | Biomarkers | en |
dc.subject | Dietary Supplements | en |
dc.subject | Goats | en |
dc.subject | Hydrogen Peroxide | en |
dc.subject | Lipid Peroxidation | en |
dc.subject | Male | en |
dc.subject | Models, Biological | en |
dc.subject | Oxidation-Reduction | en |
dc.subject | Oxidative Stress | en |
dc.subject | Rats | en |
dc.subject | Reactive Oxygen Species | en |
dc.subject | Sheep | en |
dc.subject | Whey Proteins | en |
dc.subject | Spandidos Publications | en |
dc.title | Effects of sheep/goat whey protein dietary supplementation on the redox status of rats | en |
dc.type | journalArticle | en |
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