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dc.creatorKeramidas G., Gourgoulianis K.I., Kotsiou O.S.en
dc.date.accessioned2023-01-31T08:43:14Z
dc.date.available2023-01-31T08:43:14Z
dc.date.issued2021
dc.identifier10.3390/jcm10102061
dc.identifier.issn20770383
dc.identifier.urihttp://hdl.handle.net/11615/74855
dc.description.abstractPersistent inflammation within the respiratory tract underlies the pathogenesis of numerous chronic pulmonary diseases. There is evidence supporting that chronic lung diseases are associated with a higher risk of venous thromboembolism (VTE). However, the relationship between lung diseases and/or lung function with VTE is unclear. Understanding the role of chronic lung inflammation as a predisposing factor for VTE may help determine the optimal management and aid in the development of future preventative strategies. We aimed to provide an overview of the relationship between the most common chronic inflammatory lung diseases and VTE. Asthma, chronic obstructive pulmonary disease, interstitial lung diseases, or tuberculosis increase the VTE risk, especially pulmonary embolism (PE), compared to the general population. However, high suspicion is needed to diagnose a thrombotic event early as the clinical presentation inevitably overlaps with respiratory disorders. PE risk increases with disease severity and exacerbations. Hence, hospitalized patients should be considered for thromboprophylaxis administration. Conversely, all VTE patients should be asked for lung comorbidities before determining anticoagulant therapy duration, as those patients are at increased risk of recurrent PE episodes rather than DVT. Further research is needed to understand the underlying pathophysiology of in-situ thrombosis in those patients. © 2021 by the author. Licensee MDPI, Basel, Switzerland.en
dc.language.isoenen
dc.sourceJournal of Clinical Medicineen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85113910110&doi=10.3390%2fjcm10102061&partnerID=40&md5=307fbba7a179707fe848ac20768580ae
dc.subjectasthmaen
dc.subjectchronic inflammationen
dc.subjectchronic lung diseaseen
dc.subjectchronic obstructive lung diseaseen
dc.subjecthumanen
dc.subjectinterstitial lung diseaseen
dc.subjectpneumoniaen
dc.subjectpulmonary artery thrombosisen
dc.subjectReviewen
dc.subjecttuberculosisen
dc.subjectvenous thromboembolismen
dc.subjectMDPIen
dc.titleVenous thromboembolic disease in chronic inflammatory lung diseases: Knowns and unknownsen
dc.typeotheren


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