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The role of flavonoids in inhibiting Th17 responses in inflammatory arthritis
dc.creator | Kelepouri D., Mavropoulos A., Bogdanos D.P., Sakkas L.I. | en |
dc.date.accessioned | 2023-01-31T08:43:10Z | |
dc.date.available | 2023-01-31T08:43:10Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.1155/2018/9324357 | |
dc.identifier.issn | 23148861 | |
dc.identifier.uri | http://hdl.handle.net/11615/74825 | |
dc.description.abstract | Flavonoids have been considered powerful anti-inflammatory agents, and their exact immunomodulatory action as therapeutic agents in autoimmune diseases has started to emerge. Their role in the manipulation of immunoregulation is less understood. Several studies attempted to investigate the role of various flavonoids mainly in experimental models of autoimmune diseases, especially in the context of their potential effect on the increase of regulatory T cells (Tregs) and their ability to stimulate an overexpression of anti-inflammatory cytokines, in particular that of IL-10. The emergence of IL-17, a cytokine largely produced by Th17 cells, as a powerful proinflammatory stimulus which attenuates the induction of Tregs has prompted a series of studies investigating the role of flavonoids on Th17 cells in experimental models as well as human autoimmune diseases. This review thoroughly discusses accumulated data on the role of flavonoids on Th17 in rheumatoid arthritis and experimental autoimmune arthritis. Copyright © 2018 Dimitra Kelepouri et al. | en |
dc.language.iso | en | en |
dc.source | Journal of Immunology Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85052583376&doi=10.1155%2f2018%2f9324357&partnerID=40&md5=812b27de923e941e35cdd5c09fc5de5c | |
dc.subject | anthocyanin | en |
dc.subject | flavonoid | en |
dc.subject | glycoprotein gp 130 | en |
dc.subject | Glycyrrhiza glabra root | en |
dc.subject | icariin | en |
dc.subject | interleukin 1 receptor blocking agent | en |
dc.subject | oroxylin A | en |
dc.subject | polyphenol derivative | en |
dc.subject | proanthocyanidin derivative | en |
dc.subject | procyanidin B1 | en |
dc.subject | procyanidin B2 | en |
dc.subject | procyanidin C1 | en |
dc.subject | procyanidin derivative | en |
dc.subject | unclassified drug | en |
dc.subject | antiinflammatory agent | en |
dc.subject | flavonoid | en |
dc.subject | interleukin 10 | en |
dc.subject | interleukin 17 | en |
dc.subject | apple | en |
dc.subject | autoimmune disease | en |
dc.subject | collagen-induced arthritis | en |
dc.subject | experimental arthritis | en |
dc.subject | grape | en |
dc.subject | human | en |
dc.subject | immune response | en |
dc.subject | nonhuman | en |
dc.subject | pathogenesis | en |
dc.subject | Review | en |
dc.subject | rheumatoid arthritis | en |
dc.subject | Th17 cell | en |
dc.subject | animal | en |
dc.subject | animal model | en |
dc.subject | autoimmunity | en |
dc.subject | immunology | en |
dc.subject | inflammation | en |
dc.subject | metabolism | en |
dc.subject | regulatory T lymphocyte | en |
dc.subject | rheumatoid arthritis | en |
dc.subject | Animals | en |
dc.subject | Anti-Inflammatory Agents | en |
dc.subject | Arthritis, Rheumatoid | en |
dc.subject | Autoimmunity | en |
dc.subject | Flavonoids | en |
dc.subject | Humans | en |
dc.subject | Inflammation | en |
dc.subject | Interleukin-10 | en |
dc.subject | Interleukin-17 | en |
dc.subject | Models, Animal | en |
dc.subject | T-Lymphocytes, Regulatory | en |
dc.subject | Th17 Cells | en |
dc.subject | Hindawi Limited | en |
dc.title | The role of flavonoids in inhibiting Th17 responses in inflammatory arthritis | en |
dc.type | other | en |
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