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The role of flavonoids in inhibiting Th17 responses in inflammatory arthritis

dc.creatorKelepouri D., Mavropoulos A., Bogdanos D.P., Sakkas L.I.en
dc.date.accessioned2023-01-31T08:43:10Z
dc.date.available2023-01-31T08:43:10Z
dc.date.issued2018
dc.identifier10.1155/2018/9324357
dc.identifier.issn23148861
dc.identifier.urihttp://hdl.handle.net/11615/74825
dc.description.abstractFlavonoids have been considered powerful anti-inflammatory agents, and their exact immunomodulatory action as therapeutic agents in autoimmune diseases has started to emerge. Their role in the manipulation of immunoregulation is less understood. Several studies attempted to investigate the role of various flavonoids mainly in experimental models of autoimmune diseases, especially in the context of their potential effect on the increase of regulatory T cells (Tregs) and their ability to stimulate an overexpression of anti-inflammatory cytokines, in particular that of IL-10. The emergence of IL-17, a cytokine largely produced by Th17 cells, as a powerful proinflammatory stimulus which attenuates the induction of Tregs has prompted a series of studies investigating the role of flavonoids on Th17 cells in experimental models as well as human autoimmune diseases. This review thoroughly discusses accumulated data on the role of flavonoids on Th17 in rheumatoid arthritis and experimental autoimmune arthritis. Copyright © 2018 Dimitra Kelepouri et al.en
dc.language.isoenen
dc.sourceJournal of Immunology Researchen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85052583376&doi=10.1155%2f2018%2f9324357&partnerID=40&md5=812b27de923e941e35cdd5c09fc5de5c
dc.subjectanthocyaninen
dc.subjectflavonoiden
dc.subjectglycoprotein gp 130en
dc.subjectGlycyrrhiza glabra rooten
dc.subjecticariinen
dc.subjectinterleukin 1 receptor blocking agenten
dc.subjectoroxylin Aen
dc.subjectpolyphenol derivativeen
dc.subjectproanthocyanidin derivativeen
dc.subjectprocyanidin B1en
dc.subjectprocyanidin B2en
dc.subjectprocyanidin C1en
dc.subjectprocyanidin derivativeen
dc.subjectunclassified drugen
dc.subjectantiinflammatory agenten
dc.subjectflavonoiden
dc.subjectinterleukin 10en
dc.subjectinterleukin 17en
dc.subjectappleen
dc.subjectautoimmune diseaseen
dc.subjectcollagen-induced arthritisen
dc.subjectexperimental arthritisen
dc.subjectgrapeen
dc.subjecthumanen
dc.subjectimmune responseen
dc.subjectnonhumanen
dc.subjectpathogenesisen
dc.subjectReviewen
dc.subjectrheumatoid arthritisen
dc.subjectTh17 cellen
dc.subjectanimalen
dc.subjectanimal modelen
dc.subjectautoimmunityen
dc.subjectimmunologyen
dc.subjectinflammationen
dc.subjectmetabolismen
dc.subjectregulatory T lymphocyteen
dc.subjectrheumatoid arthritisen
dc.subjectAnimalsen
dc.subjectAnti-Inflammatory Agentsen
dc.subjectArthritis, Rheumatoiden
dc.subjectAutoimmunityen
dc.subjectFlavonoidsen
dc.subjectHumansen
dc.subjectInflammationen
dc.subjectInterleukin-10en
dc.subjectInterleukin-17en
dc.subjectModels, Animalen
dc.subjectT-Lymphocytes, Regulatoryen
dc.subjectTh17 Cellsen
dc.subjectHindawi Limiteden
dc.titleThe role of flavonoids in inhibiting Th17 responses in inflammatory arthritisen
dc.typeotheren


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