dc.creator | Kalkanis A., Kalkanis D., Drougas D., Vavougios G.D., Datseris I., Judson M.A., Georgiou E. | en |
dc.date.accessioned | 2023-01-31T08:29:26Z | |
dc.date.available | 2023-01-31T08:29:26Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1097/MNM.0000000000000431 | |
dc.identifier.issn | 01433636 | |
dc.identifier.uri | http://hdl.handle.net/11615/74177 | |
dc.description.abstract | Background The objective of our study was to assess the possible relationship between splenic F-18-fluorodeoxyglucose (18F-FDG) uptake and other established biochemical markers of sarcoidosis activity. Patients and methods Thirty treatment-naive sarcoidosis patients were prospectively enrolled in this study. They underwent biochemical laboratory tests, including serum interleukin-2 receptor (sIL-2R), serum C-reactive protein, serum angiotensin-I converting enzyme, and 24-h urine calcium levels, and a whole-body combined 18F-FDG PET/computed tomography (PET/CT) scan as a part of an ongoing study at our institute. These biomarkers were statistically compared in these patients. Results A statistically significant linear dependence was detected between sIL-2R and log-transformed spleen-average standard uptake value (SUV avg) (R 2 =0.488, P<0.0001) and log-transformed spleen-maximum standard uptake value (SUV max) (R 2 =0.490, P<0.0001). sIL-2R levels and splenic size correlated linearly (Pearson's r=0.373, P=0.042). Multivariate linear regression analysis revealed that this correlation remained significant after age and sex adjustment (β=0.001, SE=0.001, P=0.024). No statistically significant associations were detected between (a) any two serum biomarkers or (b) between spleen-SUV measurements and any serum biomarker other than sIL-2R. Conclusion Our analysis revealed an association between sIL-2R levels and spleen 18F-FDG uptake and size, whereas all other serum biomarkers were not significantly associated with each other or with PET 18F-FDG uptake. Our results suggest that splenic inflammation may be related to the systemic inflammatory response in sarcoidosis that may be associated with elevated sIL-2R levels. © 2016 Wolters Kluwer Health, Inc. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Nuclear Medicine Communications | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946615837&doi=10.1097%2fMNM.0000000000000431&partnerID=40&md5=42bb08de4197ea381f1c061db04dbfa1 | |
dc.subject | biological marker | en |
dc.subject | C reactive protein | en |
dc.subject | calcium | en |
dc.subject | dipeptidyl carboxypeptidase | en |
dc.subject | fluorodeoxyglucose f 18 | en |
dc.subject | interleukin 2 receptor | en |
dc.subject | biological marker | en |
dc.subject | fluorodeoxyglucose f 18 | en |
dc.subject | interleukin 2 receptor | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | calcium urine level | en |
dc.subject | chemical parameters | en |
dc.subject | clinical article | en |
dc.subject | computer assisted emission tomography | en |
dc.subject | controlled study | en |
dc.subject | drug uptake | en |
dc.subject | female | en |
dc.subject | human | en |
dc.subject | male | en |
dc.subject | PET-CT scanner | en |
dc.subject | prospective study | en |
dc.subject | protein blood level | en |
dc.subject | sarcoidosis | en |
dc.subject | spleen | en |
dc.subject | spleen function | en |
dc.subject | spleen metabolism | en |
dc.subject | splenomegaly | en |
dc.subject | standard uptake value | en |
dc.subject | tissue metabolism | en |
dc.subject | whole body scintiscanning | en |
dc.subject | blood | en |
dc.subject | diagnostic imaging | en |
dc.subject | metabolism | en |
dc.subject | positron emission tomography | en |
dc.subject | sarcoidosis | en |
dc.subject | spleen | en |
dc.subject | transport at the cellular level | en |
dc.subject | Adult | en |
dc.subject | Biological Transport | en |
dc.subject | Biomarkers | en |
dc.subject | Female | en |
dc.subject | Fluorodeoxyglucose F18 | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Positron-Emission Tomography | en |
dc.subject | Receptors, Interleukin-2 | en |
dc.subject | Sarcoidosis | en |
dc.subject | Spleen | en |
dc.subject | Lippincott Williams and Wilkins | en |
dc.title | Correlation of spleen metabolism assessed by 18F-FDG PET with serum interleukin-2 receptor levels and other biomarkers in patients with untreated sarcoidosis | en |
dc.type | journalArticle | en |