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Conjugate eye deviation as predictor of acute cortical and subcortical ischemic brain lesions
dc.creator | Kaditis D.G., Zintzaras E., Sali D., Kotoulas G., Papadimitriou A., Hadjigeorgiou G.M. | en |
dc.date.accessioned | 2023-01-31T08:29:07Z | |
dc.date.available | 2023-01-31T08:29:07Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1016/j.clineuro.2016.02.011 | |
dc.identifier.issn | 03038467 | |
dc.identifier.uri | http://hdl.handle.net/11615/74130 | |
dc.description.abstract | Objectives Non-enhanced computed tomography (NECT) of the brain is used to exclude intracranial hemorrhage in patients who are considered for treatment with tissue plasminogen activator due to stroke symptoms. However, early infarct signs on NECT have low sensitivity for ischemic stroke. It was hypothesized that horizontal conjugate eye deviation (average ocular gaze deviation-OGD >14°) on NECT predicts ischemic brain injury on a second detailed examination. Patients and methods Patients who underwent brain NECT within three hours after the onset of stroke symptoms and subsequently had brain CT scan with intravenous contrast or MRI were potential participants. OGD was measured from the cross-sectional image including both globes at their maximum diameter. Results 73 subjects were studied (mean age 64.2 ± 20.8 years) with a median interval (interquartile range) of 56 h (22-109.3 h) between NECT and the second examination. On NECT, 24 of 73 (32.9%) subjects had OGD >14°. Of 32 individuals with acute ischemic injury on the second examination, 19 (59.4%) had OGD >14° on NECT. OGD >14° was associated with increased risk of ischemic injury: OR = 10.5 (95% confidence interval 3.33-33.9); P = 0.002. OGD >14° had significantly higher sensitivity and negative predictive value than early infarct signs on NECT (59.4% vs. 21.9% and 73.5% vs. 59.7%, respectively; P < 0.05), and similar specificity and positive predictive value (87.8% vs. 90.2% and 79.2% vs. 63.6%; P > 0.05). Conclusion In the presence of stroke symptoms, average OGD >14° on the initial brain NECT is early predictor of ischemic brain injury. © 2016 Elsevier B.V. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Clinical Neurology and Neurosurgery | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84958818872&doi=10.1016%2fj.clineuro.2016.02.011&partnerID=40&md5=95aeca236e3c5d9a507551a269f00e4a | |
dc.subject | contrast medium | en |
dc.subject | adult | en |
dc.subject | Article | en |
dc.subject | basal ganglion | en |
dc.subject | brain atrophy | en |
dc.subject | brain infarction | en |
dc.subject | brain ischemia | en |
dc.subject | computed tomography scanner | en |
dc.subject | computer assisted tomography | en |
dc.subject | conjugate eye deviation | en |
dc.subject | contrast enhancement | en |
dc.subject | controlled clinical trial | en |
dc.subject | controlled study | en |
dc.subject | diagnostic test accuracy study | en |
dc.subject | diagnostic value | en |
dc.subject | female | en |
dc.subject | gait disorder | en |
dc.subject | gait instability | en |
dc.subject | headache | en |
dc.subject | human | en |
dc.subject | image analysis | en |
dc.subject | inferior frontal gyrus | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | medical parameters | en |
dc.subject | middle cerebral artery | en |
dc.subject | nuclear magnetic resonance imaging | en |
dc.subject | ocular gaze deviation | en |
dc.subject | predictive value | en |
dc.subject | prospective study | en |
dc.subject | sensitivity and specificity | en |
dc.subject | vertigo | en |
dc.subject | acute disease | en |
dc.subject | aged | en |
dc.subject | brain ischemia | en |
dc.subject | diagnostic imaging | en |
dc.subject | Intracranial Hemorrhages | en |
dc.subject | middle aged | en |
dc.subject | strabismus | en |
dc.subject | Stroke | en |
dc.subject | very elderly | en |
dc.subject | x-ray computed tomography | en |
dc.subject | Acute Disease | en |
dc.subject | Aged | en |
dc.subject | Aged, 80 and over | en |
dc.subject | Brain Ischemia | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Intracranial Hemorrhages | en |
dc.subject | Magnetic Resonance Imaging | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Predictive Value of Tests | en |
dc.subject | Prospective Studies | en |
dc.subject | Strabismus | en |
dc.subject | Stroke | en |
dc.subject | Tomography, X-Ray Computed | en |
dc.subject | Elsevier B.V. | en |
dc.title | Conjugate eye deviation as predictor of acute cortical and subcortical ischemic brain lesions | en |
dc.type | journalArticle | en |
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