Εμφάνιση απλής εγγραφής

dc.creatorHaider D.G., Klemenz T., Fiedler G.M., Nakas C.T., Exadaktylos A.K., Leichtle A.B.en
dc.date.accessioned2023-01-31T08:27:27Z
dc.date.available2023-01-31T08:27:27Z
dc.date.issued2017
dc.identifier10.1016/j.ijcard.2016.10.043
dc.identifier.issn01675273
dc.identifier.urihttp://hdl.handle.net/11615/73769
dc.description.abstractBackground High sensitive cardiac troponin T (hs-TnT) found its way into everyday clinical routine to diagnose acute myocardial infarction (AMI). However, its levels vary considerably based on the underlying pathophysiology of the patients. Hence we sought to test the applicability of the currently only available hs-TnT assay (Roche Diagnostics, Switzerland) to diagnose acute myocardial infarction. Methods and patients Retrospectively, we analyzed the hs-TnT results of 1573 patients admitted to a level A university hospital emergency department. Overall 323 patients had an acute cardiac event defined as Non-ST Elevated Myocardial Infarction (NSTEMI) and 286 patients had a ST-Elevated Myocardial Infarction (STEMI). 964 patients served as controls, consisting of patients with other cardiac and non-cardiac morbidity. Results The sensitivity of hs-TnT for detecting an acute cardiac event was more than 92% overall. The specificity varied around 35% depending on the respective patient cohort. ROC curve analysis of the initial hs-TnT results showed that the AUC in total cardiac events (STEMI and NSTEMI) was 0.81. Detailed analysis resulted in an AUC of 0.79 in NSTEMI and 0.84 in STEMI patients detected via the initial hs-TnT. We further tested the ESC algorithm for detecting NSTEMI and obtained a sensitivity of about 83%, while 43% of all non-NSTEMIs are classified as NSTEMIs. Conclusion We show that the specificity of hs-TnT for AMI is very low and conclude that the current assay including its delta values represents myocardial damage of any origin. This damage alone does not substantiate an AMI diagnosis even when international algorithms are applied. © 2016en
dc.language.isoenen
dc.sourceInternational Journal of Cardiologyen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84996558175&doi=10.1016%2fj.ijcard.2016.10.043&partnerID=40&md5=c55d37518ed1e9e1cfc7dc92e0d3032a
dc.subjecthigh sensitive cardiac troponin Ten
dc.subjecttroponin Ten
dc.subjectunclassified drugen
dc.subjectbiological markeren
dc.subjecttroponin Ten
dc.subjectacute heart infarctionen
dc.subjectageden
dc.subjectalgorithmen
dc.subjectarea under the curveen
dc.subjectArticleen
dc.subjectassayen
dc.subjectcohort analysisen
dc.subjectcontrolled studyen
dc.subjectdiagnostic procedureen
dc.subjectdiagnostic test accuracy studyen
dc.subjectdisease classificationen
dc.subjectfemaleen
dc.subjecthospital patienten
dc.subjecths TnT assayen
dc.subjecthumanen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectmorbidityen
dc.subjectnon ST segment elevation myocardial infarctionen
dc.subjectpriority journalen
dc.subjectreceiver operating characteristicen
dc.subjectretrospective studyen
dc.subjectsensitivity analysisen
dc.subjectsensitivity and specificityen
dc.subjectST segment elevation myocardial infarctionen
dc.subjectblooden
dc.subjectheart infarctionen
dc.subjectmiddle ageden
dc.subjectpredictive valueen
dc.subjectSwitzerlanden
dc.subjectvery elderlyen
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectBiomarkersen
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyocardial Infarctionen
dc.subjectPredictive Value of Testsen
dc.subjectRetrospective Studiesen
dc.subjectROC Curveen
dc.subjectSwitzerlanden
dc.subjectTroponin Ten
dc.subjectElsevier Ireland Ltden
dc.titleHigh sensitive cardiac troponin T: Testing the testen
dc.typejournalArticleen


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