dc.creator | Hadjigeorgiou G.F., Singh R., Dardiotis E., Paterakis K., Hadjigeorgiou G.M., Fountas K.N. | en |
dc.date.accessioned | 2023-01-31T08:27:25Z | |
dc.date.available | 2023-01-31T08:27:25Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.23736/s0390-5616.16.03589-X | |
dc.identifier.issn | 03905616 | |
dc.identifier.uri | http://hdl.handle.net/11615/73759 | |
dc.description.abstract | Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Identification of endogenous neuroprotective mechanisms after TBI and the development of therapeutic targets to improve TBI outcomes are areas of intense scientific research. In this review, we summarize genetically modified TBI mouse models and highlight the recent scientific findings from using such models, including mediators of inflammation, programmed cell death and metabolism, modulators of vascular tone and membrane channel proteins. A deeper understanding of the complex biochemical processes and genetic pathways in TBi could offer personalized genomic-based therapies for and improve clinical outcomes in TBI patients. © 2016 Edizioni Minerva Medica. | en |
dc.language.iso | en | en |
dc.source | Journal of Neurosurgical Sciences | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85031320074&doi=10.23736%2fs0390-5616.16.03589-X&partnerID=40&md5=45cad54bea90189143efcfd8595f6847 | |
dc.subject | adenosine A1 receptor | en |
dc.subject | adenosine A2 receptor | en |
dc.subject | amyloid precursor protein | en |
dc.subject | bradykinin B1 receptor | en |
dc.subject | bradykinin B2 receptor | en |
dc.subject | calpain 1 | en |
dc.subject | chemokine receptor CXCR2 | en |
dc.subject | cyclooxygenase 1 | en |
dc.subject | fibronectin | en |
dc.subject | heat shock protein | en |
dc.subject | intercellular adhesion molecule 2 | en |
dc.subject | interleukin 6 | en |
dc.subject | neurotrophin | en |
dc.subject | protein bcl 2 | en |
dc.subject | tumor necrosis factor | en |
dc.subject | animal cell | en |
dc.subject | animal model | en |
dc.subject | gene inactivation | en |
dc.subject | mouse | en |
dc.subject | neuroprotection | en |
dc.subject | nonhuman | en |
dc.subject | Review | en |
dc.subject | traumatic brain injury | en |
dc.subject | tumor suppressor gene | en |
dc.subject | animal | en |
dc.subject | disease model | en |
dc.subject | gene knockout | en |
dc.subject | knockout mouse | en |
dc.subject | traumatic brain injury | en |
dc.subject | Animals | en |
dc.subject | Brain Injuries, Traumatic | en |
dc.subject | Disease Models, Animal | en |
dc.subject | Gene Knockout Techniques | en |
dc.subject | Mice, Knockout | en |
dc.subject | Edizioni Minerva Medica | en |
dc.title | Traumatic brain injury and gene knockout animal models: An up-to-date review | en |
dc.type | other | en |