A case-control study on the risk factors for meningococcal disease among children in Greece
dc.creator | Hadjichristodoulou C., Mpalaouras G., Vasilopoulou V., Katsioulis A., Rachiotis G., Theodoridou K., Tzanakaki G., Syriopoulou V., Theodoridou M. | en |
dc.date.accessioned | 2023-01-31T08:27:24Z | |
dc.date.available | 2023-01-31T08:27:24Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1371/journal.pone.0158524 | |
dc.identifier.issn | 19326203 | |
dc.identifier.uri | http://hdl.handle.net/11615/73750 | |
dc.description.abstract | Purpose: The aim of this study was to identify environmental or genetic risk factors that are associated with invasive meningococcal disease (IMD) in children in Greece. Methods: A case-control study was performed in 133 children (44 cases and 89 controls) aged between 0-14 years, who were hospitalized in a children's hospital in Athens. Demographics and possible risk factors were collected by the use of a structured questionnaire. To investigate the association of mannose binding lectin (MBL) with IMD, a frequency analysis of the haplotypes of the MBL2 gene and quantitative measurement of MBL serum protein levels were performed using Nanogen NanoChipR 400 technology and immuno-enzyme techniques, respectively. Results: The multivariate analysis revealed that changes in a child's life setting (relocation or vacation, OR = 7.16), paternal smoking (OR = 4.51), upper respiratory tract infection within the previous month (OR = 3.04) and the density of people in the house/100m2 (OR = 3.16), were independent risk factors associated with IMD. Overall 18.8%of patients had a MBL2 genotype with low functionality compared to 10.1% of healthy controls, but this was not statistically significant (p = 0.189). Conclusion: Prevention strategies aimed at reducing parental smoking and other risk factors identified in this study could decrease the risk of IMD among children in Greece. © 2016 Hadjichristodoulou et al. | en |
dc.language.iso | en | en |
dc.source | PLoS ONE | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978162009&doi=10.1371%2fjournal.pone.0158524&partnerID=40&md5=f5b271a4c892ef9a98a2d8a02523d4ff | |
dc.subject | mannose binding lectin | en |
dc.subject | mannose binding lectin 2 | en |
dc.subject | mannose binding lectin | en |
dc.subject | MBL2 protein, human | en |
dc.subject | passive smoking | en |
dc.subject | adolescent | en |
dc.subject | Article | en |
dc.subject | case control study | en |
dc.subject | child | en |
dc.subject | child hospitalization | en |
dc.subject | controlled study | en |
dc.subject | demography | en |
dc.subject | environmental factor | en |
dc.subject | enzyme immunoassay | en |
dc.subject | female | en |
dc.subject | genetic analysis | en |
dc.subject | genetic risk | en |
dc.subject | genotype | en |
dc.subject | Greece | en |
dc.subject | haplotype | en |
dc.subject | human | en |
dc.subject | infant | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | MBL2 gene | en |
dc.subject | meningococcosis | en |
dc.subject | multivariate analysis | en |
dc.subject | newborn | en |
dc.subject | paternal smoking | en |
dc.subject | pediatric hospital | en |
dc.subject | protein blood level | en |
dc.subject | questionnaire | en |
dc.subject | risk factor | en |
dc.subject | structured questionnaire | en |
dc.subject | upper respiratory tract infection | en |
dc.subject | blood | en |
dc.subject | genetics | en |
dc.subject | Meningococcal Infections | en |
dc.subject | passive smoking | en |
dc.subject | preschool child | en |
dc.subject | Respiratory Tract Infections | en |
dc.subject | Adolescent | en |
dc.subject | Case-Control Studies | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Female | en |
dc.subject | Genotype | en |
dc.subject | Greece | en |
dc.subject | Haplotypes | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Male | en |
dc.subject | Mannose-Binding Lectin | en |
dc.subject | Meningococcal Infections | en |
dc.subject | Respiratory Tract Infections | en |
dc.subject | Tobacco Smoke Pollution | en |
dc.subject | Public Library of Science | en |
dc.title | A case-control study on the risk factors for meningococcal disease among children in Greece | en |
dc.type | journalArticle | en |
Dateien zu dieser Ressource
Dateien | Größe | Format | Anzeige |
---|---|---|---|
Zu diesem Dokument gibt es keine Dateien. |