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Chloroquine used in combination with chemotherapy synergistically suppresses growth and angiogenesis in vitro and in vivo

dc.creatorGurel-Gurevin E., Tuba Kiyan H., Esener O.B.B., Aydinlik S., Uvez A., Ulukaya E., Dimas K., Armutak E.I.en
dc.date.accessioned2023-01-31T08:27:22Z
dc.date.available2023-01-31T08:27:22Z
dc.date.issued2018
dc.identifier10.21873/anticanres.12689
dc.identifier.issn02507005
dc.identifier.urihttp://hdl.handle.net/11615/73738
dc.description.abstractBackground: The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance to anti-angiogenic therapy. Materials and Methods: The cytotoxic effect of doxorubicin (0.1-1 μM), chloroquine (0.25-32 μM) and their combination were investigated by employing ATP assay in human umbilical vein endothelial cells (HUVECs). The effect of doxorubicin and chloroquine combination was also measured using tube formation assay on Matrigel. The anti-angiogenic activities of doxorubicin (2.5 μg/pellet) and chloroquine (15 μg/pellet), their combination, and standards (50 μg/pellet) were tested in vivo using the chick embryo chorioallantoic membrane (CAM) assay. Results: The combination of doxorubicin and chloroquine significantly had a stronger anti-angiogenic effect than the positive control (±)-thalidomide and doxorubicin alone in the CAM assay and in vitro tube-formation assay. Conclusion: Chloroquine enhanced the anti-angiogenic effect of doxorubicin on CAM at the tested concentrations. © 2018 International Institute of Anticancer Research. All rights reserved.en
dc.language.isoenen
dc.sourceAnticancer Researchen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85049800874&doi=10.21873%2fanticanres.12689&partnerID=40&md5=7380424e865ded8296d2cd16c6fd7bd3
dc.subjectchloroquineen
dc.subjectcortisoneen
dc.subjectdoxorubicinen
dc.subjectprednisoneen
dc.subjectthalidomideen
dc.subjectadenosine triphosphateen
dc.subjectangiogenesis inhibitoren
dc.subjectantineoplastic antibioticen
dc.subjectchloroquineen
dc.subjectdoxorubicinen
dc.subjectantiangiogenic activityen
dc.subjectArticleen
dc.subjectcancer chemotherapyen
dc.subjectcancer inhibitionen
dc.subjectcell viabilityen
dc.subjectchorioallantoic membrane assayen
dc.subjectcontrolled studyen
dc.subjectdrug cytotoxicityen
dc.subjectdrug potentiationen
dc.subjecthumanen
dc.subjecthuman cellen
dc.subjectin vitro studyen
dc.subjectin vivo studyen
dc.subjectpriority journalen
dc.subjectumbilical vein endothelial cellen
dc.subjectanimalen
dc.subjectautophagyen
dc.subjectcell proliferationen
dc.subjectchick embryoen
dc.subjectchorioallantoisen
dc.subjectcombination drug therapyen
dc.subjectdrug effecten
dc.subjectdrug potentiationen
dc.subjectmetabolismen
dc.subjectneovascularization (pathology)en
dc.subjectAdenosine Triphosphateen
dc.subjectAngiogenesis Inhibitorsen
dc.subjectAnimalsen
dc.subjectAntibiotics, Antineoplasticen
dc.subjectAutophagyen
dc.subjectCell Proliferationen
dc.subjectChick Embryoen
dc.subjectChloroquineen
dc.subjectChorioallantoic Membraneen
dc.subjectDoxorubicinen
dc.subjectDrug Synergismen
dc.subjectDrug Therapy, Combinationen
dc.subjectHuman Umbilical Vein Endothelial Cellsen
dc.subjectHumansen
dc.subjectNeovascularization, Pathologicen
dc.subjectInternational Institute of Anticancer Researchen
dc.titleChloroquine used in combination with chemotherapy synergistically suppresses growth and angiogenesis in vitro and in vivoen
dc.typejournalArticleen


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