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Association of Vitamin D Receptor Gene Polymorphisms with Serum Vitamin D Levels in a Greek Rural Population (Velestino Study)
dc.creator | Divanoglou N., Komninou D., Stea E.A., Argiriou A., Papatzikas G., Tsakalof A., Pazaitou-Panayiotou K., Georgakis M.K., Petridou E. | en |
dc.date.accessioned | 2023-01-31T07:57:24Z | |
dc.date.available | 2023-01-31T07:57:24Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.1159/000514338 | |
dc.identifier.issn | 25043161 | |
dc.identifier.uri | http://hdl.handle.net/11615/73384 | |
dc.description.abstract | Background/Aim: An alarming increase in vitamin D deficiency even in sunny regions highlights the need for a better understanding of the genetic background of the vitamin D endocrine system and the molecular mechanisms of gene polymorphisms of the vitamin D receptor (VDR). In this study, the serum levels of 25(OH)D3 were correlated with common VDR polymorphisms (ApaI, BsmI, FokI, and TaqI) in 98 subjects of a Greek homogeneous rural population. Methods: 25(OH)D3 concentration was measured by ultra-HPLC, and the VDR gene polymorphisms were identified by quantitative real-time PCR followed by amplicon high-resolution melting analysis. Results: Subjects carrying either the B BsmI (OR: 0.52, 95% CI: 0.27-0.99) or t TaqI (OR: 2.06, 95%: 1.06-3.99) allele presented twice the risk for developing vitamin D deficiency compared to the reference allele. Moreover, subjects carrying 1, 2, or all 3 of these genotypes (BB/Bb, Tt/tt, and FF) demonstrated 2-fold (OR: 2.04, 95% CI: 0.42-9.92), 3.6-fold (OR: 3.62, 95% CI: 1.07-12.2), and 7-fold (OR: 6.92, 95% CI: 1.68-28.5) increased risk for low 25(OH)D3 levels, respectively. Conclusions: Our findings reveal a cumulative effect of specific VDR gene polymorphisms that may regulate vitamin D concentrations explaining, in part, the paradox of vitamin D deficiency in sunny regions, with important implications for precision medicine. © 2021 The Author(s). Published by S. Karger AG, Basel. | en |
dc.language.iso | en | en |
dc.source | Lifestyle Genomics | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109093467&doi=10.1159%2f000514338&partnerID=40&md5=66afb63f14701b37bb24042f72914a6a | |
dc.subject | vitamin D | en |
dc.subject | vitamin D receptor | en |
dc.subject | calcitriol receptor | en |
dc.subject | vitamin D | en |
dc.subject | adult | en |
dc.subject | allele | en |
dc.subject | amplicon | en |
dc.subject | anthropometric parameters | en |
dc.subject | Article | en |
dc.subject | body composition | en |
dc.subject | controlled study | en |
dc.subject | female | en |
dc.subject | genetic association | en |
dc.subject | genetic polymorphism | en |
dc.subject | genetic susceptibility | en |
dc.subject | genotype | en |
dc.subject | Greece | en |
dc.subject | high performance liquid chromatography | en |
dc.subject | high resolution melting analysis | en |
dc.subject | human | en |
dc.subject | human tissue | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | nutrigenetics | en |
dc.subject | observational study | en |
dc.subject | protein blood level | en |
dc.subject | protein function | en |
dc.subject | quantitative analysis | en |
dc.subject | real time polymerase chain reaction | en |
dc.subject | receptor gene | en |
dc.subject | rural population | en |
dc.subject | ultra performance liquid chromatography | en |
dc.subject | vitamin blood level | en |
dc.subject | vitamin D deficiency | en |
dc.subject | epidemiology | en |
dc.subject | genetic polymorphism | en |
dc.subject | genetic predisposition | en |
dc.subject | genetics | en |
dc.subject | rural population | en |
dc.subject | Genetic Predisposition to Disease | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Polymorphism, Genetic | en |
dc.subject | Receptors, Calcitriol | en |
dc.subject | Rural Population | en |
dc.subject | Vitamin D | en |
dc.subject | S. Karger AG | en |
dc.title | Association of Vitamin D Receptor Gene Polymorphisms with Serum Vitamin D Levels in a Greek Rural Population (Velestino Study) | en |
dc.type | journalArticle | en |
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