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dc.creatorDiamantopoulos P., Koumbi D., Kotsianidis I., Pappa V., Symeonidis A., Galanopoulos A., Zikos P., Papadaki H.A., Panayiotidis P., Dimou M., Hatzimichael E., Vassilopoulos G., Delimpasis S., Mparmparousi D., Papageorgiou S., Variami E., Kyrtsonis M.-C., Megalakaki A., Kotsopoulou M., Repousis P., Adamopoulos I., Kontopidou F., Christoulas D., Kourakli A., Tsokanas D., Konstantinos Papoutselis M., Kyriakakis G., Viniou N.-A., the Hellenic MDS study groupen
dc.date.accessioned2023-01-31T07:54:54Z
dc.date.available2023-01-31T07:54:54Z
dc.date.issued2019
dc.identifier10.1002/cam4.2090
dc.identifier.issn20457634
dc.identifier.urihttp://hdl.handle.net/11615/73275
dc.description.abstractIn patients with myelodysplastic syndrome (MDS), the prognostic significance of chromosome 17 abnormalities has not yet been fully elucidated, except for isochromosome 17q that has been characterized as an intermediate risk abnormality in the Revised International Prognostic Scoring System (IPSS-R). To further characterize the prognostic significance of chromosome 17 abnormalities we analyzed the hematologic and prognostic characteristics of 548 adult patients with MDS treated with 5-azacytidine through the Hellenic 5-azacytidine registry and found 32 patients with a chromosome 17 abnormality (6 with i[17q], 15 with -17, 3 with add[17p] and the rest with other rarer abnormalities, mostly translocations). The presence of a chromosome 17 abnormality was correlated with poor prognostic features (high IPSS, IPSS-R, and WPSS scores) and a low overall survival rate (15.7 vs 36.4 months for patients without chromosome 17 abnormalities, Kaplan–Meier, Log Rank P < 0.00001), but these results were confounded by the fact that most (92.3%) of the cases with a chromosome 17 abnormality (with the exception of i(17q) that was found in all cases as an isolated abnormality) were found in the context of a complex karyotype. Nevertheless, one should not ignore the contribution of chromosome 17 abnormalities to the prognostic significance of a complex karyotype since 33.8% of complex karyotypes encompassed a chromosome 17 abnormality. © 2019 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.en
dc.language.isoenen
dc.sourceCancer Medicineen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85066403991&doi=10.1002%2fcam4.2090&partnerID=40&md5=13d17081089f10a96dbb14e831bf4c10
dc.subjectazacitidineen
dc.subjectantineoplastic antimetaboliteen
dc.subjectazacitidineen
dc.subjectadulten
dc.subjectArticleen
dc.subjectcancer prognosisen
dc.subjectcancer registryen
dc.subjectcancer regressionen
dc.subjectchromosome 17en
dc.subjectchromosome aberrationen
dc.subjectchromosome additionen
dc.subjectchromosome deletionen
dc.subjectchromosome inversionen
dc.subjectchromosome translocationen
dc.subjectcorrelation analysisen
dc.subjectfemaleen
dc.subjecthumanen
dc.subjectInternational Prognostic Scoring Systemen
dc.subjectKaplan Meier methoden
dc.subjectkaryotypeen
dc.subjectmajor clinical studyen
dc.subjectmaleen
dc.subjectmultiple cycle treatmenten
dc.subjectmyelodysplastic syndromeen
dc.subjectoverall survivalen
dc.subjectpriority journalen
dc.subjectprognostic assessmenten
dc.subjectretrospective studyen
dc.subjecttreatment outcomeen
dc.subjectWorld Health Organization classification based Prognostic Scoring Systemen
dc.subjectageden
dc.subjectgeneticsen
dc.subjectmiddle ageden
dc.subjectmyelodysplastic syndromeen
dc.subjectprognosisen
dc.subjectvery elderlyen
dc.subjectAdulten
dc.subjectAgeden
dc.subjectAged, 80 and overen
dc.subjectAntimetabolites, Antineoplasticen
dc.subjectAzacitidineen
dc.subjectChromosomes, Human, Pair 17en
dc.subjectFemaleen
dc.subjectHumansen
dc.subjectMaleen
dc.subjectMiddle Ageden
dc.subjectMyelodysplastic Syndromesen
dc.subjectPrognosisen
dc.subjectBlackwell Publishing Ltden
dc.titleThe prognostic significance of chromosome 17 abnormalities in patients with myelodysplastic syndrome treated with 5-azacytidine: Results from the Hellenic 5-azacytidine registryen
dc.typejournalArticleen


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