dc.creator | Deli C.K., Fatouros I.G., Paschalis V., Tsiokanos A., Georgakouli K., Zalavras A., Avloniti A., Koutedakis Y., Jamurtas A.Z. | en |
dc.date.accessioned | 2023-01-31T07:52:48Z | |
dc.date.available | 2023-01-31T07:52:48Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1155/2017/4120421 | |
dc.identifier.issn | 19420900 | |
dc.identifier.uri | http://hdl.handle.net/11615/73175 | |
dc.description.abstract | Exercise-induced skeletal muscle microtrauma is characterized by loss of muscle cell integrity, marked aseptic inflammatory response, and oxidative stress. We examined if iron supplementation would alter redox status after eccentric exercise. In a randomized, double blind crossover study, that was conducted in two cycles, healthy adults (n=14) and children (n=11) received daily either 37 mg of elemental iron or placebo for 3 weeks prior to and up to 72 h after an acute eccentric exercise bout. Blood was drawn at baseline, before exercise, and 72 h after exercise for the assessment of iron status, creatine kinase activity (CK), and redox status. Iron supplementation at rest increased iron concentration and transferrin saturation (p<0.01). In adults, CK activity increased at 72 h after exercise, while no changes occurred in children. Iron supplementation increased TBARS at 72 h after exercise in both adults and children; no changes occurred under placebo condition. Eccentric exercise decreased bilirubin concentration at 72 h in all groups. Iron supplementation can alter redox responses after muscle-damaging exercise in both adults and children. This could be of great importance not only for healthy exercising individuals, but also in clinical conditions which are characterized by skeletal muscle injury and inflammation, yet iron supplementation is crucial for maintaining iron homeostasis. This study was registered at Clinicaltrials.gov Identifier: NCT02374619. © 2017 Chariklia K. Deli et al. | en |
dc.language.iso | en | en |
dc.source | Oxidative Medicine and Cellular Longevity | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85010707062&doi=10.1155%2f2017%2f4120421&partnerID=40&md5=ae3fdf974f691e5e0a465df9499745b9 | |
dc.subject | Muscle | en |
dc.subject | Clinical conditions | en |
dc.subject | Creatine kinase | en |
dc.subject | Eccentric exercise | en |
dc.subject | Elemental iron | en |
dc.subject | Inflammatory response | en |
dc.subject | Iron concentrations | en |
dc.subject | Iron homeostasis | en |
dc.subject | Skeletal muscle | en |
dc.subject | Iron | en |
dc.subject | bilirubin | en |
dc.subject | carbonyl derivative | en |
dc.subject | catalase | en |
dc.subject | creatine kinase | en |
dc.subject | glutathione | en |
dc.subject | placebo | en |
dc.subject | resoferon | en |
dc.subject | thiobarbituric acid reactive substance | en |
dc.subject | transferrin | en |
dc.subject | uric acid | en |
dc.subject | iron | en |
dc.subject | reactive nitrogen species | en |
dc.subject | reactive oxygen metabolite | en |
dc.subject | adult | en |
dc.subject | adult disease | en |
dc.subject | Article | en |
dc.subject | aseptic skeletal muscle injury | en |
dc.subject | aseptic skeletal muscle injury | en |
dc.subject | bicycle ergometry | en |
dc.subject | child | en |
dc.subject | childhood injury | en |
dc.subject | controlled study | en |
dc.subject | creatine kinase blood level | en |
dc.subject | crossover procedure | en |
dc.subject | double blind procedure | en |
dc.subject | eccentric muscle contraction | en |
dc.subject | enzyme activity | en |
dc.subject | ferritin blood level | en |
dc.subject | groups by age | en |
dc.subject | human | en |
dc.subject | iron binding capacity | en |
dc.subject | iron therapy | en |
dc.subject | lipid peroxidation | en |
dc.subject | male | en |
dc.subject | muscle injury | en |
dc.subject | normal human | en |
dc.subject | oxidation reduction reaction | en |
dc.subject | oxidative stress | en |
dc.subject | randomized controlled trial | en |
dc.subject | rest | en |
dc.subject | school child | en |
dc.subject | skeletal muscle | en |
dc.subject | treatment duration | en |
dc.subject | adolescent | en |
dc.subject | age | en |
dc.subject | dietary supplement | en |
dc.subject | drug effects | en |
dc.subject | exercise | en |
dc.subject | injuries | en |
dc.subject | metabolism | en |
dc.subject | middle aged | en |
dc.subject | oxidative stress | en |
dc.subject | physiology | en |
dc.subject | skeletal muscle | en |
dc.subject | young adult | en |
dc.subject | Iron Compounds | en |
dc.subject | Oxidation | en |
dc.subject | Redox Reactions | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Age Factors | en |
dc.subject | Child | en |
dc.subject | Cross-Over Studies | en |
dc.subject | Dietary Supplements | en |
dc.subject | Double-Blind Method | en |
dc.subject | Exercise | en |
dc.subject | Humans | en |
dc.subject | Iron | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Muscle, Skeletal | en |
dc.subject | Oxidation-Reduction | en |
dc.subject | Oxidative Stress | en |
dc.subject | Reactive Nitrogen Species | en |
dc.subject | Reactive Oxygen Species | en |
dc.subject | Young Adult | en |
dc.subject | Hindawi Limited | en |
dc.title | Iron Supplementation Effects on Redox Status following Aseptic Skeletal Muscle Trauma in Adults and Children | en |
dc.type | journalArticle | en |