Current evidence on the effect of dietary polyphenols intake on chronic diseases

Costa C., Tsatsakis A., Mamoulakis C., Teodoro M., Briguglio G., Caruso E., Tsoukalas D., Margina D., Dardiotis E., Kouretas D., Fenga C.

dc.creator	Costa C., Tsatsakis A., Mamoulakis C., Teodoro M., Briguglio G., Caruso E., Tsoukalas D., Margina D., Dardiotis E., Kouretas D., Fenga C.	en
dc.date.accessioned	2023-01-31T07:48:06Z
dc.date.available	2023-01-31T07:48:06Z
dc.date.issued	2017
dc.identifier	10.1016/j.fct.2017.10.023
dc.identifier.issn	02786915
dc.identifier.uri	http://hdl.handle.net/11615/72958
dc.description.abstract	Polyphenols are secondary metabolites of plants. They comprise several antioxidant compounds and they are generally considered to be involved in the defense against human chronic diseases. During the last years, there has been growing scientific interest in their potential health benefits. In this comprehensive review, we focus on the current evidence defining the position of their dietary intake in the prevention/treatment of human chronic diseases, including prostate cancer and other types of cancer, cardiovascular diseases, diabetes mellitus and neurodegenerative diseases such as Alzheimer's and Parkinson's disease; we also discuss their ability to modulate multiple signalling transduction pathways involved in the pathophysiology of these diseases. Despite the fact that data regarding the biological functions of polyphenols can be considered exhaustive, evidence is still inadequate to support clear beneficial effects on human chronic diseases. Currently, most data suggest that a combination of phytochemicals rather than any single polyphenol is responsible for health benefit. More studies investigating the role of polyphenols in the prevention of chronic human diseases are needed, especially for evaluating factors such as gender, age, genotype, metabolism and bioavailability. © 2017 Elsevier Ltd	en
dc.language.iso	en	en
dc.source	Food and Chemical Toxicology	en
dc.source.uri	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85032470469&doi=10.1016%2fj.fct.2017.10.023&partnerID=40&md5=54a27037ea2ce12b3627e53dbc0ca87c
dc.subject	3 indolemethanol	en
dc.subject	3,3' diindolylmethane	en
dc.subject	anthocyanidin	en
dc.subject	anthocyanin	en
dc.subject	curcumin	en
dc.subject	ellagitannin	en
dc.subject	epigallocatechin gallate	en
dc.subject	isoflavone derivative	en
dc.subject	lycopene	en
dc.subject	polyphenol	en
dc.subject	rosmarinic acid	en
dc.subject	unclassified drug	en
dc.subject	polyphenol	en
dc.subject	Alzheimer disease	en
dc.subject	cardiovascular disease	en
dc.subject	chronic disease	en
dc.subject	diabetes mellitus	en
dc.subject	dietary intake	en
dc.subject	disease course	en
dc.subject	human	en
dc.subject	incidence	en
dc.subject	intervention study	en
dc.subject	nonhuman	en
dc.subject	Parkinson disease	en
dc.subject	practice guideline	en
dc.subject	prevalence	en
dc.subject	prostate cancer	en
dc.subject	Review	en
dc.subject	risk factor	en
dc.subject	signal transduction	en
dc.subject	systematic review	en
dc.subject	analysis	en
dc.subject	animal	en
dc.subject	chronic disease	en
dc.subject	dietary supplement	en
dc.subject	oxidative stress	en
dc.subject	Animals	en
dc.subject	Chronic Disease	en
dc.subject	Dietary Supplements	en
dc.subject	Humans	en
dc.subject	Oxidative Stress	en
dc.subject	Polyphenols	en
dc.subject	Elsevier Ltd	en
dc.title	Current evidence on the effect of dietary polyphenols intake on chronic diseases	en
dc.type	other	en

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Background National levels of personal health-care access and quality can be approximated by measuring mortality rates from causes that should not be fatal in the presence of effective medical care (ie, amenable mortality). ...
SARS-CoV-2 pathophysiology and its clinical implications: An integrative overview of the pharmacotherapeutic management of COVID-19

Tsatsakis A., Calina D., Falzone L., Petrakis D., Mitrut R., Siokas V., Pennisi M., Lanza G., Libra M., Doukas S.G., Doukas P.G., Kavali L., Bukhari A., Gadiparthi C., Vageli D.P., Kofteridis D.P., Spandidos D.A., Paoliello M.M.B., Aschner M., Docea A.O. (2020)

Common manifestations of COVID-19 are respiratory and can extend from mild symptoms to severe acute respiratory distress. The severity of the illness can also extend from mild disease to life-threatening acute respiratory ...

Current evidence on the effect of dietary polyphenols intake on chronic diseases

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