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Gsh levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy
dc.creator | Goutzourelas N., Orfanou M., Charizanis I., Leon G., Spandidos D.A., Kouretas D. | en |
dc.date.accessioned | 2023-01-31T07:44:22Z | |
dc.date.available | 2023-01-31T07:44:22Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.3892/etm.2018.6204 | |
dc.identifier.issn | 17920981 | |
dc.identifier.uri | http://hdl.handle.net/11615/72689 | |
dc.description.abstract | This study examined the effects of redox status markers on metabolic syndrome (MetS) and obesity before and after dietary intervention and exercise for weight loss. A total of 103 adults suffering from MetS and obesity participated in this study and followed a personalized diet plan for 6 months. Body weight, body fat (BF) percentage (BF%), respiratory quotient (RQ) and the redox status markers, reduced glutathione (GSH), thiobarbituric acid reactive substances (TBARS) and protein carbonyls (CARB), were measured twice in each individual, before and after intervention. Dietary intervention resulted in weight loss, a reduction in BF% and a decrease in RQ. The GSH levels were significantly decreased following intervention, while the levels of TBARS and CARB were not affected. Based on the initial GSH levels, the patients were divided into 2 groups as follows: The high GSH group (GSH, >3.5 µmol/g Hb) and the low GSH group (GSH <3.5 µmol/g Hb). Greater weight and BF loss were observed in patients with high GSH levels. It was observed that patients with MetS and obesity with high GSH values responded better to the dietary therapy, exhibiting more significant changes in weight and BF%. This finding underscores the importance of identifying redox status markers, particularly GSH, in obese patients with MetS. Knowing the levels of GSH may aid in developing a better design of an individualized dietary plan for individuals who wish to lose weight. © 2018, Spandidos Publications. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | Experimental and Therapeutic Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85049138124&doi=10.3892%2fetm.2018.6204&partnerID=40&md5=14339dc1593f918ebcbdab9dd3f3331c | |
dc.subject | carbon dioxide | en |
dc.subject | carbonyl derivative | en |
dc.subject | glutathione | en |
dc.subject | malonaldehyde | en |
dc.subject | oxygen | en |
dc.subject | thiobarbituric acid derivative | en |
dc.subject | thiobarbituric acid reactive substance | en |
dc.subject | adult | en |
dc.subject | antioxidant assay | en |
dc.subject | Article | en |
dc.subject | blood analysis | en |
dc.subject | body fat | en |
dc.subject | body mass | en |
dc.subject | body weight loss | en |
dc.subject | cardiovascular risk | en |
dc.subject | diabetes mellitus | en |
dc.subject | diet therapy | en |
dc.subject | eating habit | en |
dc.subject | enzyme activity | en |
dc.subject | exercise | en |
dc.subject | female | en |
dc.subject | genetic background | en |
dc.subject | glycemic load | en |
dc.subject | human | en |
dc.subject | insulin resistance | en |
dc.subject | kinesiotherapy | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | metabolic syndrome X | en |
dc.subject | obesity | en |
dc.subject | oxidative stress | en |
dc.subject | personalized medicine | en |
dc.subject | respiratory quotient | en |
dc.subject | spectrophotometry | en |
dc.subject | Spandidos Publications | en |
dc.title | Gsh levels affect weight loss in individuals with metabolic syndrome and obesity following dietary therapy | en |
dc.type | journalArticle | en |
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