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Oxidative stress response is mediated by overexpression and spatiotemporal regulation of caveolin-1
dc.creator | Goutas A., Papathanasiou I., Mourmoura E., Tsesmelis K., Tsezou A., Trachana V. | en |
dc.date.accessioned | 2023-01-31T07:44:15Z | |
dc.date.available | 2023-01-31T07:44:15Z | |
dc.date.issued | 2020 | |
dc.identifier | 10.3390/antiox9080766 | |
dc.identifier.issn | 20763921 | |
dc.identifier.uri | http://hdl.handle.net/11615/72673 | |
dc.description.abstract | Oxidative stress (OS) has been linked to the aetiology of many diseases including osteoarthritis (OA). Recent studies have shown that caveolin-1—a structural protein of plasma membrane’s caveolae—is upregulated in response to OS. Here, we explore the function of caveolin-1 in chondrocytes derived from healthy individuals (control) and OA patients that were subjected to exogenous OS. We showed that caveolin-1 was upregulated in response to acute OS in the control, but not in OA chondrocytes. Moreover, OS-induced DNA damage analysis revealed that control cells started repairing the DNA lesions 6 h post-oxidative treatment, while OA cells seemed unable to restore these damages. Importantly, in the control cells, we observed a translocation of caveolin-1 from the membrane/cytoplasm in and out of the nucleus, which coincided with the appearance and restoration of DNA lesions. When caveolin-1 was prevented from translocating to the nucleus, the control cells were unable to repair DNA damage. In OA cells, no such translocation of caveolin-1 was observed, which could account for their inability to repair DNA damage. Taken together, these results provide novel insights considering the role of caveolin-1 in response to OS-induced DNA damage while revealing its implication in the pathophysiology of OA. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.language.iso | en | en |
dc.source | Antioxidants | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090811927&doi=10.3390%2fantiox9080766&partnerID=40&md5=cd1b5c170eb4982f223ea93839402dcb | |
dc.subject | MDPI | en |
dc.title | Oxidative stress response is mediated by overexpression and spatiotemporal regulation of caveolin-1 | en |
dc.type | journalArticle | en |
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