dc.creator | Chatzileontiadou D.S.M., Tsirkone V.G., Dossi K., Kassouni A.G., Liggri P.G.V., Kantsadi A.L., Stravodimos G.A., Balatsos N.A.A., Skamnaki V.T., Leonidas D.D. | en |
dc.date.accessioned | 2023-01-31T07:44:05Z | |
dc.date.available | 2023-01-31T07:44:05Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1002/1873-3468.12335 | |
dc.identifier.issn | 00145793 | |
dc.identifier.uri | http://hdl.handle.net/11615/72652 | |
dc.description.abstract | In this study, we investigate the inhibition of human angiogenin by ammonium sulfate. The inhibitory potency of ammonium sulfate for human angiogenin (IC50 = 123.5 ± 14.9 mm) is comparable to that previously reported for RNase A (119.0 ± 6.5 mm) and RNase 2 (95.7 ± 9.3 mm). However, analysis of two X-ray crystal structures of human angiogenin in complex with sulfate anions (in acidic and basic pH environments, respectively) indicates an entirely distinct mechanism of inhibition. While ammonium sulfate inhibits the ribonucleolytic activity of RNase A and RNase 2 by binding to the active site of these enzymes, sulfate anions bind only to peripheral substrate anion-binding subsites of human angiogenin, and not to the active site. © 2016 Federation of European Biochemical Societies | en |
dc.language.iso | en | en |
dc.source | FEBS Letters | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84985906119&doi=10.1002%2f1873-3468.12335&partnerID=40&md5=42a5d4c148c4d2fe7f6572f0dd6acf22 | |
dc.subject | ammonium sulfate | en |
dc.subject | angiogenin | en |
dc.subject | anion | en |
dc.subject | ribonuclease | en |
dc.subject | ribonuclease 2 | en |
dc.subject | ribonuclease A | en |
dc.subject | unclassified drug | en |
dc.subject | binding site | en |
dc.subject | controlled study | en |
dc.subject | crystal structure | en |
dc.subject | enzyme active site | en |
dc.subject | enzyme activity | en |
dc.subject | enzyme binding | en |
dc.subject | enzyme inhibition | en |
dc.subject | IC50 | en |
dc.subject | inhibition kinetics | en |
dc.subject | Letter | en |
dc.subject | pH measurement | en |
dc.subject | priority journal | en |
dc.subject | structure activity relation | en |
dc.subject | structure analysis | en |
dc.subject | X ray crystallography | en |
dc.subject | Wiley Blackwell | en |
dc.title | The ammonium sulfate inhibition of human angiogenin | en |
dc.type | journalArticle | en |