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A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate
dc.creator | Giakountis A., Moulos P., Zarkou V., Oikonomou C., Harokopos V., Hatzigeorgiou A.G., Reczko M., Hatzis P. | en |
dc.date.accessioned | 2023-01-31T07:41:34Z | |
dc.date.available | 2023-01-31T07:41:34Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1016/j.celrep.2016.05.038 | |
dc.identifier.issn | 22111247 | |
dc.identifier.uri | http://hdl.handle.net/11615/72271 | |
dc.description.abstract | The canonical Wnt pathway plays a central role in stem cell maintenance, differentiation, and proliferation in the intestinal epithelium. Constitutive, aberrant activity of the TCF4/β-catenin transcriptional complex is the primary transforming factor in colorectal cancer. We identify a nuclear long non-coding RNA, termed WiNTRLINC1, as a direct target of TCF4/β-catenin in colorectal cancer cells. WiNTRLINC1 positively regulates the expression of its genomic neighbor ASCL2, a transcription factor that controls intestinal stem cell fate. WiNTRLINC1 interacts with TCF4/β-catenin to mediate the juxtaposition of its promoter with the regulatory regions of ASCL2. ASCL2, in turn, regulates WiNTRLINC1 transcriptionally, closing a feedforward regulatory loop that controls stem cell-related gene expression. This regulatory circuitry is highly amplified in colorectal cancer and correlates with increased metastatic potential and decreased patient survival. Our results uncover the interplay between non-coding RNA-mediated regulation and Wnt signaling and point to the diagnostic and therapeutic potential of WiNTRLINC1. © 2016 The Author(s). | en |
dc.language.iso | en | en |
dc.source | Cell Reports | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84975138424&doi=10.1016%2fj.celrep.2016.05.038&partnerID=40&md5=c4e8ed6d1296382c4ba5f2939d2980b8 | |
dc.subject | beta catenin | en |
dc.subject | long untranslated RNA | en |
dc.subject | membrane protein | en |
dc.subject | protein ASCL2 | en |
dc.subject | RNA polymerase II | en |
dc.subject | unclassified drug | en |
dc.subject | WNT regulated lincRNA 1 | en |
dc.subject | ASCL2 protein, human | en |
dc.subject | basic helix loop helix transcription factor | en |
dc.subject | long non-coding RNA WiNTRLINC1, human | en |
dc.subject | long untranslated RNA | en |
dc.subject | acetylation | en |
dc.subject | Article | en |
dc.subject | chromatin immunoprecipitation | en |
dc.subject | controlled study | en |
dc.subject | gene amplification | en |
dc.subject | gene expression profiling | en |
dc.subject | gene expression regulation | en |
dc.subject | genetic transcription | en |
dc.subject | high throughput sequencing | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | intestinal stem cell | en |
dc.subject | molecular cloning | en |
dc.subject | polyadenylation | en |
dc.subject | priority journal | en |
dc.subject | promoter region | en |
dc.subject | protein conformation | en |
dc.subject | protein RNA binding | en |
dc.subject | transcription initiation site | en |
dc.subject | transcription regulation | en |
dc.subject | Wnt signaling pathway | en |
dc.subject | cell lineage | en |
dc.subject | colorectal tumor | en |
dc.subject | genetics | en |
dc.subject | intestine | en |
dc.subject | metabolism | en |
dc.subject | pathology | en |
dc.subject | stem cell | en |
dc.subject | tumor cell line | en |
dc.subject | Wnt signaling | en |
dc.subject | Basic Helix-Loop-Helix Transcription Factors | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Cell Lineage | en |
dc.subject | Colorectal Neoplasms | en |
dc.subject | Gene Expression Regulation, Neoplastic | en |
dc.subject | Humans | en |
dc.subject | Intestines | en |
dc.subject | RNA, Long Noncoding | en |
dc.subject | Stem Cells | en |
dc.subject | Wnt Signaling Pathway | en |
dc.subject | Elsevier B.V. | en |
dc.title | A Positive Regulatory Loop between a Wnt-Regulated Non-coding RNA and ASCL2 Controls Intestinal Stem Cell Fate | en |
dc.type | journalArticle | en |
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