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Complications after Anterior Temporal Lobectomy for Medically Intractable Epilepsy: A Systematic Review and Meta-Analysis
dc.creator | Brotis A.G., Giannis T., Kapsalaki E., Dardiotis E., Fountas K.N. | en |
dc.date.accessioned | 2023-01-31T07:40:36Z | |
dc.date.available | 2023-01-31T07:40:36Z | |
dc.date.issued | 2019 | |
dc.identifier | 10.1159/000500136 | |
dc.identifier.issn | 10116125 | |
dc.identifier.uri | http://hdl.handle.net/11615/72116 | |
dc.description.abstract | The efficacy of surgery in the management of patients with longstanding temporal lobe epilepsy has been established. Anterior temporal lobectomy (ATL) is the most frequently implemented procedure. However, there is an obvious need to assess its perioperative safety. Objective: We conducted a meta-analysis to estimate the postoperative mortality (Q1) and morbidity (Q2) associated with ATL for medically intractable epilepsy. In addition, we tried to identify the most frequent complications after ATL and assess their relative frequency (Q3) in children and adults. Methods: Fixed- and random-effects model meta-analysis was conducted to assess the proportion estimate for each outcome individually. Results: The postoperative mortality and cumulative morbidity were estimated to be as high as 0.01 (95% CI: 0.01, 0.02) and 0.17 (95% CI: 0.12, 0.24), respectively. Psychiatric disorders were the most common postoperative complications after ATL, with an estimated frequency as high as 0.07 (95% CI: 0.04, 0.10), followed by visual field defects (0.06; 0.03, 0.11), and cognitive disorders (0.05; 0.02, 0.10). Less frequent complications included hemiparesis and language disorders (0.03; 0.01, 0.06), infections (0.03; 0.02, 0.04), hemorrhage (0.02; 0.01, 0.05), cranial nerve deficits (0.03; 0.02, 0.05), extra-axial fluid collections (0.02; 0.01, 0.03), and medical complications (0.02; 0.01, 0.03). Conclusions: Even though the mortality after ATL is minimal, the overall morbidity cannot be ignored. Psychiatric disturbances, visual field defects, and cognitive disorders are the most common postoperative complications, and should be considered during the preoperative planning and consultation. © 2019 S. Karger AG, Basel. | en |
dc.language.iso | en | en |
dc.source | Stereotactic and Functional Neurosurgery | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85070829431&doi=10.1159%2f000500136&partnerID=40&md5=10eb022d2accdd33860534744cf0993b | |
dc.subject | bleeding | en |
dc.subject | cognitive defect | en |
dc.subject | evidence based medicine | en |
dc.subject | hemiparesis | en |
dc.subject | human | en |
dc.subject | infection | en |
dc.subject | intractable epilepsy | en |
dc.subject | language disability | en |
dc.subject | mental disease | en |
dc.subject | meta analysis | en |
dc.subject | morbidity | en |
dc.subject | mortality | en |
dc.subject | postoperative period | en |
dc.subject | Review | en |
dc.subject | surgical mortality | en |
dc.subject | systematic review | en |
dc.subject | temporal lobectomy | en |
dc.subject | treatment outcome | en |
dc.subject | visual field defect | en |
dc.subject | adolescent | en |
dc.subject | adult | en |
dc.subject | adverse event | en |
dc.subject | child | en |
dc.subject | drug resistant epilepsy | en |
dc.subject | female | en |
dc.subject | male | en |
dc.subject | mental disease | en |
dc.subject | postoperative complication | en |
dc.subject | temporal lobe epilepsy | en |
dc.subject | temporal lobectomy | en |
dc.subject | visual disorder | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Anterior Temporal Lobectomy | en |
dc.subject | Child | en |
dc.subject | Drug Resistant Epilepsy | en |
dc.subject | Epilepsy, Temporal Lobe | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Mental Disorders | en |
dc.subject | Postoperative Complications | en |
dc.subject | Treatment Outcome | en |
dc.subject | Vision Disorders | en |
dc.subject | S. Karger AG | en |
dc.title | Complications after Anterior Temporal Lobectomy for Medically Intractable Epilepsy: A Systematic Review and Meta-Analysis | en |
dc.type | other | en |
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