Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece
dc.creator | Gatselis N.K., Zachou K., Lygoura V., Azariadis K., Arvaniti P., Spyrou E., Papadamou G., Koukoulis G.K., Dalekos G.N., Rigopoulou E.I. | en |
dc.date.accessioned | 2023-01-31T07:39:53Z | |
dc.date.available | 2023-01-31T07:39:53Z | |
dc.date.issued | 2017 | |
dc.identifier | 10.1016/j.ejim.2017.05.006 | |
dc.identifier.issn | 09536205 | |
dc.identifier.uri | http://hdl.handle.net/11615/71995 | |
dc.description.abstract | Background & aims Primary biliary cholangitis (PBC) is a disease with rising prevalence and considerable geographical variation. To describe the prevalence, spatial and time distribution, baseline characteristics, response to treatment, outcome and the validity of GLOBE score in a large cohort of Greek PBC patients as an independent validation of this score has not been done so far. Methods The last 16 years, 482 PBC patients (86.5% females) were evaluated and analysed retrospectively, using a prospectively collected database. Special attention was paid to the assessment of treatment response according to GLOBE score. Results Age at initial evaluation was 56.3 ± 13.7 years. Among 432 Thessaly residents, prevalence was 582/million (non-homogeneous distribution). Nineteen districts showed a prevalence > 800/million. Symptomatic disease onset could be identified in 91 patients, with a significant peak during spring (P = 0.03). At diagnosis, 43.6% were asymptomatic and 16.2% cirrhotic. Male sex (P = 0.02), older age (P < 0.001), alcohol consumption (P < 0.01) and concomitant liver disease (P < 0.001) were negative prognostic factors for cirrhosis. During a median [interquartile range, range] follow-up of 5.1 (7.8, 15.7) years, 62 patients died or underwent liver transplantation. Patients with GLOBE score > 0.30 had significantly worse prognosis (P < 0.001) with 5-, 10-, and 15-year survival rates of 84%, 50% and 42%. Conclusions There is increased PBC prevalence in Thessaly with remarkable geographic clustering and seasonal variability. PBC is diagnosed at early stages although males had a more advanced disease. GLOBE score applies perfectly in Greek patients and this will likely help detecting patients that may benefit from new therapies. © 2017 European Federation of Internal Medicine | en |
dc.language.iso | en | en |
dc.source | European Journal of Internal Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019911422&doi=10.1016%2fj.ejim.2017.05.006&partnerID=40&md5=ca16885c8081390af888b7079ef55ea1 | |
dc.subject | ursodeoxycholic acid | en |
dc.subject | autoantibody | en |
dc.subject | abdominal pain | en |
dc.subject | adult | en |
dc.subject | age | en |
dc.subject | alcohol consumption | en |
dc.subject | anaphylactoid purpura | en |
dc.subject | Article | en |
dc.subject | asymptomatic disease | en |
dc.subject | cholangitis | en |
dc.subject | clinical feature | en |
dc.subject | comparative study | en |
dc.subject | controlled study | en |
dc.subject | digestive system disease assessment | en |
dc.subject | erythema nodosum | en |
dc.subject | evaluation study | en |
dc.subject | female | en |
dc.subject | follow up | en |
dc.subject | geographic distribution | en |
dc.subject | GLOBE score | en |
dc.subject | Greece | en |
dc.subject | human | en |
dc.subject | liver disease | en |
dc.subject | liver transplantation | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | middle aged | en |
dc.subject | musculoskeletal pain | en |
dc.subject | pharmaceutical care | en |
dc.subject | prevalence | en |
dc.subject | primary biliary cholangitis | en |
dc.subject | primary biliary cirrhosis | en |
dc.subject | prognosis | en |
dc.subject | pruritus | en |
dc.subject | retrospective study | en |
dc.subject | rural area | en |
dc.subject | scoring system | en |
dc.subject | seasonal variation | en |
dc.subject | sex difference | en |
dc.subject | Sjoegren syndrome | en |
dc.subject | spring | en |
dc.subject | surgical mortality | en |
dc.subject | survival rate | en |
dc.subject | treatment outcome | en |
dc.subject | treatment response | en |
dc.subject | urban area | en |
dc.subject | vitiligo | en |
dc.subject | aged | en |
dc.subject | biliary cirrhosis | en |
dc.subject | blood | en |
dc.subject | cholangitis | en |
dc.subject | complication | en |
dc.subject | drinking behavior | en |
dc.subject | liver cell carcinoma | en |
dc.subject | liver tumor | en |
dc.subject | multivariate analysis | en |
dc.subject | risk factor | en |
dc.subject | season | en |
dc.subject | statistical model | en |
dc.subject | survival analysis | en |
dc.subject | Adult | en |
dc.subject | Aged | en |
dc.subject | Alcohol Drinking | en |
dc.subject | Autoantibodies | en |
dc.subject | Carcinoma, Hepatocellular | en |
dc.subject | Cholangitis | en |
dc.subject | Female | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Liver Cirrhosis, Biliary | en |
dc.subject | Liver Neoplasms | en |
dc.subject | Liver Transplantation | en |
dc.subject | Logistic Models | en |
dc.subject | Male | en |
dc.subject | Middle Aged | en |
dc.subject | Multivariate Analysis | en |
dc.subject | Retrospective Studies | en |
dc.subject | Risk Factors | en |
dc.subject | Seasons | en |
dc.subject | Survival Analysis | en |
dc.subject | Treatment Outcome | en |
dc.subject | Elsevier B.V. | en |
dc.title | Geoepidemiology, clinical manifestations and outcome of primary biliary cholangitis in Greece | en |
dc.type | journalArticle | en |
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