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Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas?
dc.creator | Fotakopoulos G., Fountas K., Tsianaka E., Kotlia P., Pachatouridis D., Paschalis T., Voulgaris S. | en |
dc.date.accessioned | 2023-01-31T07:38:22Z | |
dc.date.available | 2023-01-31T07:38:22Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.4155/fsoa-2017-0103 | |
dc.identifier.issn | 20565623 | |
dc.identifier.uri | http://hdl.handle.net/11615/71669 | |
dc.description.abstract | Aim: To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection. Patients & methods: This retrospective study included 65 patients (34 male, 52.3%) with VS operated in between January 2009 and April 2014 (follow-up 3.2 ± 0.7 years). Preoperative or postoperative IGF-I levels were identified for each patient. Results: Patients were divided into two groups: Group A (small size tumor), 56 patients; and Group B (large size tumor), 9 cases. IGF-I levels in Group A (195.8 ± 32.9 ng/ml) were compared with those of Group B (242.2 ± 22.2 ng/ml) and were found to have statistically significant difference (p = 0.001). Conclusion: Increased IGF-I levels could hold a key role in nerve recovery in patients undergoing surgical resection of large VS. Lay abstract The aim of this study was to examine the possible correlation between IGF-I levels in serum in large vestibular schwannomas (VS) and its potential neuroprotective effect on the vestibulocochlear nerve. This retrospective study included 65 patients that underwent surgery, 9 of whom were diagnosed with large VS. Results suggested that elevated IGF-I in serum levels could help identify patients with large VS with better neuroprotective activity. © 2018 2017 George Fotakopoulos. | en |
dc.language.iso | en | en |
dc.source | Future Science OA | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069007672&doi=10.4155%2ffsoa-2017-0103&partnerID=40&md5=2c8710cd785b8e4ec459c80956b17836 | |
dc.subject | somatomedin C receptor | en |
dc.subject | acoustic neuroma | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | Article | en |
dc.subject | computer assisted tomography | en |
dc.subject | enzyme linked immunosorbent assay | en |
dc.subject | facial nerve injury | en |
dc.subject | female | en |
dc.subject | growth hormone release | en |
dc.subject | histopathology | en |
dc.subject | human | en |
dc.subject | length of stay | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | nerve regeneration | en |
dc.subject | neurologic examination | en |
dc.subject | neuroprotection | en |
dc.subject | priority journal | en |
dc.subject | receiver operating characteristic | en |
dc.subject | retrospective study | en |
dc.subject | sensitivity and specificity | en |
dc.subject | tumor volume | en |
dc.subject | vestibulocochlear nerve | en |
dc.subject | Future Medicine Ltd. | en |
dc.title | Could IGF-I levels play a neuroprotective role in patients with large vestibular schwannomas? | en |
dc.type | journalArticle | en |
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