Mostra i principali dati dell'item
Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study
dc.creator | Flouris A.D., Dinas P.C., Nintou E., Psychou D., Granzotto M., Rossato M., Vettor R., Jamurtas A.Z., Koutedakis Y., Metsios G.S. | en |
dc.date.accessioned | 2023-01-31T07:38:13Z | |
dc.date.available | 2023-01-31T07:38:13Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.12688/f1000research.14198.2 | |
dc.identifier.issn | 20461402 | |
dc.identifier.uri | http://hdl.handle.net/11615/71635 | |
dc.description.abstract | Background: Atrial natriuretic peptide increases lipolysis in human adipocytes by binding to natriuretic peptide receptor-A (NPRA). The aim of the current study was to examine the associations of NPRA mRNA of subcutaneous adipose tissue with fat mass, fat-free mass, body mass index (BMI) and arterial blood pressure in medication-free healthy men. Method: Thirty-two volunteers [age (years): 36.067.36, BMI: 27.604.63 (kg/m 2)] underwent assessments of body height/weight, % fat mass, fat-free mass (kg), blood pressure, and a subcutaneous adipose tissue biopsy via a surgical technique. Results: We found that NPRA mRNA was negatively associated with % fat mass (r=-0.40, R 2=0.16, p=0.03) and BMI (r=-0.45, R 2=0.20, p=0.01). Cohen's f 2 effect size analyses showed a small effect size between NPRA mRNA and BMI ( f 2 =0.25). One-way analysis of variance with Bonferroni post-hoc tests showed a tendency for mean differences of NPRA mRNA across BMI categories (p=0.06). This was confirmed by Cohen's d effect size analyses revealing a large effect size of NPRA mRNA between obese individuals (BMI≥30 kg/m 2) and either normal weight (BMI=19-25 kg/m 2; d=0.94) or overweight (BMI=25-30 kg/m 2; d=1.12) individuals. Conclusions: NPRA mRNA is negatively associated with % fat mass and BMI in medication-free healthy men, suggesting a possible role of NPRA in the control of fat mass accumulation. © 2018 Dinas PC et al. | en |
dc.language.iso | en | en |
dc.source | F1000Research | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050280518&doi=10.12688%2ff1000research.14198.2&partnerID=40&md5=4c2eb0e6805d24512ea59b2b148bd038 | |
dc.subject | messenger RNA | en |
dc.subject | natriuretic peptide receptor A | en |
dc.subject | adult | en |
dc.subject | arterial pressure | en |
dc.subject | Article | en |
dc.subject | biopsy | en |
dc.subject | body height | en |
dc.subject | body mass | en |
dc.subject | body weight | en |
dc.subject | cross-sectional study | en |
dc.subject | fat free mass | en |
dc.subject | fat mass | en |
dc.subject | human | en |
dc.subject | human experiment | en |
dc.subject | lipid storage | en |
dc.subject | male | en |
dc.subject | normal human | en |
dc.subject | subcutaneous fat | en |
dc.subject | surgical technique | en |
dc.subject | F1000 Research Ltd | en |
dc.title | Association of fat mass profile with natriuretic peptide receptor alpha in subcutaneous adipose tissue of medication-free healthy men: A cross-sectional study | en |
dc.type | journalArticle | en |
Files in questo item
Files | Dimensione | Formato | Mostra |
---|---|---|---|
Nessun files in questo item. |