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Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases
dc.creator | Filippou P.S., Ren A.H., Korbakis D., Dimitrakopoulos L., Soosaipillai A., Barak V., Frenkel S., Pe'Er J., Lotem M., Merims S., Molina R., Blasutig I., Bogdanos D.P., Diamandis E.P. | en |
dc.date.accessioned | 2023-01-31T07:38:02Z | |
dc.date.available | 2023-01-31T07:38:02Z | |
dc.date.issued | 2018 | |
dc.identifier | 10.1515/cclm-2018-0139 | |
dc.identifier.issn | 14346621 | |
dc.identifier.uri | http://hdl.handle.net/11615/71587 | |
dc.description.abstract | Mucin 13 (MUC13) is a cell surface glycoprotein aberrantly expressed in a variety of epithelial carcinomas. Thus far, the role of MUC13 in various diseases remains elusive. To the best of our knowledge, this is the first study to examine the potential of MUC13 as a serum biomarker in a variety of carcinomas and other conditions. We developed a recombinant MUC13 protein, mouse monoclonal antibodies and enzyme immunoassay (ELISA) for MUC13. We used this assay to measure MUC13 levels in the supernatants of cancer cell lines and a large cohort of serum samples from healthy and diseased individuals. MUC13 is secreted from cancer cell lines, with highest levels found in ovarian cancer cell lines. MUC13 levels in human sera were significantly increased in patients with renal failure and 20%-30% of patients with ovarian, liver, lung and other cancers. MUC13 was also elevated in 70% of patients with active cutaneous melanoma, but not uveal melanoma. Furthermore, we identified significant MUC13 elevations in the serum of patients with vasculitis (ANCA-positive) autoantibodies, but not in those with inflammatory bowel disease. Serum MUC13 is frequently elevated not only in a variety of malignant cases but also in some benign pathologies, thus appearing to be a non-specific disease biomarker. Nonetheless, serum MUC13 is clearly highly elevated in some carcinoma patients, and its relationship with tumor progression in this context warrant further research. Future studies that examine the correlation between serum MUC13 levels to stage of cancer could elucidate prognostic potential. © 2018 2018 Walter de Gruyter GmbH, Berlin/Boston. | en |
dc.language.iso | en | en |
dc.source | Clinical Chemistry and Laboratory Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85047491798&doi=10.1515%2fcclm-2018-0139&partnerID=40&md5=d881385094b65f076a8e0d1a4f992cbd | |
dc.subject | autoantibody | en |
dc.subject | biological marker | en |
dc.subject | creatinine | en |
dc.subject | mucin | en |
dc.subject | mucin 13 | en |
dc.subject | neutrophil cytoplasmic antibody | en |
dc.subject | tumor marker | en |
dc.subject | unclassified drug | en |
dc.subject | MUC13 protein, human | en |
dc.subject | mucin | en |
dc.subject | tumor marker | en |
dc.subject | animal cell | en |
dc.subject | animal experiment | en |
dc.subject | Article | en |
dc.subject | autoimmune disease | en |
dc.subject | BT-474 cell line | en |
dc.subject | cancer patient | en |
dc.subject | cancer prognosis | en |
dc.subject | carcinoma | en |
dc.subject | colorectal cancer | en |
dc.subject | creatinine blood level | en |
dc.subject | cutaneous melanoma | en |
dc.subject | enzyme immunoassay | en |
dc.subject | enzyme linked immunosorbent assay | en |
dc.subject | ES-2 cell line (ovarian carcinoma) | en |
dc.subject | gel filtration chromatography | en |
dc.subject | HaCat cell line | en |
dc.subject | human | en |
dc.subject | human cell | en |
dc.subject | immunoassay | en |
dc.subject | kidney failure | en |
dc.subject | liver cancer | en |
dc.subject | lung cancer | en |
dc.subject | major clinical study | en |
dc.subject | MDA-MB-468 cell line | en |
dc.subject | mouse | en |
dc.subject | nonhuman | en |
dc.subject | OV-90 cell line | en |
dc.subject | ovarian cancer cell line | en |
dc.subject | ovary cancer | en |
dc.subject | OVCAR-3 cell line | en |
dc.subject | OVCAR-5 cell line | en |
dc.subject | priority journal | en |
dc.subject | protein expression | en |
dc.subject | skin cancer | en |
dc.subject | SW1088 cell line | en |
dc.subject | TOV-112D cell line | en |
dc.subject | TOV-21G cell line | en |
dc.subject | uvea melanoma | en |
dc.subject | vasculitis | en |
dc.subject | VcaP cell line | en |
dc.subject | autoimmune disease | en |
dc.subject | blood | en |
dc.subject | carcinoma | en |
dc.subject | female | en |
dc.subject | male | en |
dc.subject | melanoma | en |
dc.subject | metabolism | en |
dc.subject | ovary tumor | en |
dc.subject | procedures | en |
dc.subject | skin tumor | en |
dc.subject | tumor cell line | en |
dc.subject | Autoimmune Diseases | en |
dc.subject | Biomarkers, Tumor | en |
dc.subject | Carcinoma | en |
dc.subject | Cell Line, Tumor | en |
dc.subject | Enzyme-Linked Immunosorbent Assay | en |
dc.subject | Female | en |
dc.subject | Humans | en |
dc.subject | Male | en |
dc.subject | Melanoma | en |
dc.subject | Mucins | en |
dc.subject | Ovarian Neoplasms | en |
dc.subject | Skin Neoplasms | en |
dc.subject | De Gruyter | en |
dc.title | Exploring the potential of mucin 13 (MUC13) as a biomarker for carcinomas and other diseases | en |
dc.type | journalArticle | en |
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