Serum Neutralization Assay for the Determination of Antibody Levels Against Non-Polio Enterovirus Strains in Central and Western Greece
dc.creator | Fikatas A., Dimitriou T.G., Kyriakopoulou Z., Tsachouridou O., Gartzonika C., Levidiotou-Stefanou S., Amoutzias G.D., Markoulatos P. | en |
dc.date.accessioned | 2023-01-31T07:37:57Z | |
dc.date.available | 2023-01-31T07:37:57Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1089/vim.2016.0049 | |
dc.identifier.issn | 08828245 | |
dc.identifier.uri | http://hdl.handle.net/11615/71564 | |
dc.description.abstract | Mutations and recombination events have been identified in enteroviruses. Point mutations accumulate with a frequency of 6.3 × 10-4 per base pair per replication cycle affecting the fitness, the circulation, and the infectivity of enteroviral strains. In the present report, the serological status of the Central and Western Greek population (Larissa and Ioannina, respectively) in the 1-10-year, 11-20-year, 21-30-year, and 31-40-year age groups against six non-polio enterovirus strains, their respective echovirus prototypes, and Sabin 1, 2, and 3 vaccine strains was evaluated, through serum-neutralization assay. In the Western Greek population, antibody levels were detected only for clinical isolates of E30 serotype in all age groups, and for environmental isolate LR61G3 (E6 serotype) only in the 31-40 age group, whereas an immunity level was observed in the Central Greek population, against all strains, except for EIS6B (E3 serotype). Amino acid substitutions were encountered across the structural region of the capsid, between the prototypes and the respective isolates. These substitutions may alter the antigenicity of each strain and may explain the variations observed in the neutralization titers of the different strains. As a consequence, these substitutions severely affect antibody binding and increase the ability of the virus to escape the immune response. It is tempting to assume that changes in the antigenic properties observed in circulating echoviruses represent a selection of viral variants that are less prone to be neutralized by human antibodies. These facts argue for the need of immunological studies to the population to avoid epidemics due to the circulation of highly evolved derivatives. © Copyright 2016, Mary Ann Liebert, Inc. | en |
dc.language.iso | en | en |
dc.source | Viral Immunology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84986333466&doi=10.1089%2fvim.2016.0049&partnerID=40&md5=c344ff0b1dcabfb0e364320b3cf093ee | |
dc.subject | amino acid | en |
dc.subject | neutralizing antibody | en |
dc.subject | capsid protein | en |
dc.subject | neutralizing antibody | en |
dc.subject | virus antibody | en |
dc.subject | adolescent | en |
dc.subject | adult | en |
dc.subject | age | en |
dc.subject | amino acid substitution | en |
dc.subject | antibody blood level | en |
dc.subject | antibody detection | en |
dc.subject | antibody titer | en |
dc.subject | antigen binding | en |
dc.subject | antigenicity | en |
dc.subject | Article | en |
dc.subject | child | en |
dc.subject | clinical article | en |
dc.subject | controlled study | en |
dc.subject | Enterovirus | en |
dc.subject | Enterovirus E3 | en |
dc.subject | Enterovirus E30 | en |
dc.subject | Enterovirus E6 | en |
dc.subject | Enterovirus E7 | en |
dc.subject | Greece | en |
dc.subject | human | en |
dc.subject | immune evasion | en |
dc.subject | nonhuman | en |
dc.subject | nucleotide sequence | en |
dc.subject | serology | en |
dc.subject | virus capsid | en |
dc.subject | virus immunity | en |
dc.subject | virus isolation | en |
dc.subject | virus neutralization | en |
dc.subject | virus strain | en |
dc.subject | blood | en |
dc.subject | Enterovirus | en |
dc.subject | Enterovirus infection | en |
dc.subject | genetics | en |
dc.subject | immunology | en |
dc.subject | infant | en |
dc.subject | preschool child | en |
dc.subject | procedures | en |
dc.subject | serodiagnosis | en |
dc.subject | seroepidemiology | en |
dc.subject | young adult | en |
dc.subject | Adolescent | en |
dc.subject | Adult | en |
dc.subject | Amino Acid Substitution | en |
dc.subject | Antibodies, Neutralizing | en |
dc.subject | Antibodies, Viral | en |
dc.subject | Capsid Proteins | en |
dc.subject | Child | en |
dc.subject | Child, Preschool | en |
dc.subject | Enterovirus | en |
dc.subject | Enterovirus Infections | en |
dc.subject | Greece | en |
dc.subject | Humans | en |
dc.subject | Infant | en |
dc.subject | Neutralization Tests | en |
dc.subject | Seroepidemiologic Studies | en |
dc.subject | Young Adult | en |
dc.subject | Mary Ann Liebert Inc. | en |
dc.title | Serum Neutralization Assay for the Determination of Antibody Levels Against Non-Polio Enterovirus Strains in Central and Western Greece | en |
dc.type | journalArticle | en |
Αρχεία σε αυτό το τεκμήριο
Αρχεία | Μέγεθος | Τύπος | Προβολή |
---|---|---|---|
Δεν υπάρχουν αρχεία που να σχετίζονται με αυτό το τεκμήριο. |