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Somatic evolution and global expansion of an ancient transmissible cancer lineage

dc.creatorBaez-Ortega A., Gori K., Strakova A., Allen J.L., Allum K.M., Bansse-Issa L., Bhutia T.N., Bisson J.L., Briceño C., Domracheva A.C., Corrigan A.M., Cran H.R., Crawford J.T., Davis E., De Castro K.F., De Nardi A.B., De Vos A.P., Keenan L.D., Donelan E.M., Espinoza Huerta A.R., Faramade I.A., Fazil M., Fotopoulou E., Fruean S.N., Gallardo-Arrieta F., Glebova O., Gouletsou P.G., Häfelin Manrique R.F., Henriques J.J.G.P., Horta R.S., Ignatenko N., Kane Y., King C., Koenig D., Krupa A., Kruzeniski S.J., Kwon Y.-M., Lanza-Perea M., Lazyan M., Lopez Quintana A.M., Losfelt T., Marino G., Castañeda S.M., Martínez-López M.F., Meyer M., Migneco E.J., Nakanwagi B., Neal K.B., Neunzig W., Leathlobhair M.N., Nixon S.J., Ortega-Pacheco A., Pedraza-Ordoñez F., Peleteiro M.C., Polak K., Pye R.J., Reece J.F., Gutierrez J.R., Sadia H., Schmeling S.K., Shamanova O., Sherlock A.G., Stammnitz M., Steenland-Smit A.E., Svitich A., Tapia Martínez L.J., Ngoka I.T., Torres C.G., Tudor E.M., Van Der Wel M.G., Viţălaru B.A., Vural S.A., Walkinton O., Wang J., Wehrle-Martinez A.S., Widdowson S.A.E., Stratton M.R., Alexandrov L.B., Martincorena I., Murchison E.P.en
dc.date.accessioned2023-01-31T07:35:04Z
dc.date.available2023-01-31T07:35:04Z
dc.date.issued2019
dc.identifier10.1126/science.aau9923
dc.identifier.issn00368075
dc.identifier.urihttp://hdl.handle.net/11615/71038
dc.description.abstractThe canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by “metastasizing” between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution. © 2019 American Association for the Advancement of Science. All rights reserved.en
dc.language.isoenen
dc.sourceScienceen
dc.source.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85071029662&doi=10.1126%2fscience.aau9923&partnerID=40&md5=8f5c9f8d910e3a0fb6b5b67bf7f4d067
dc.subjectdouble stranded DNAen
dc.subjectmitochondrial DNAen
dc.subjectcanceren
dc.subjectgenetic driften
dc.subjectmutationen
dc.subjectphylogenyen
dc.subjectphylogeographyen
dc.subjecttumoren
dc.subjectultraviolet radiationen
dc.subjectanimal venereal tumoren
dc.subjectArticleen
dc.subjectcanine transmissible venereal tumoren
dc.subjectdisease transmissionen
dc.subjectDNA damageen
dc.subjectgene expressionen
dc.subjectgenetic driften
dc.subjectgenetic variabilityen
dc.subjectgenomic instabilityen
dc.subjectmalignant neoplasmen
dc.subjectmutational analysisen
dc.subjectnonhumanen
dc.subjectnonsense mutationen
dc.subjectphylogenetic treeen
dc.subjectphylogeographyen
dc.subjectpriority journalen
dc.subjectsomatic mutationen
dc.subjectultraviolet radiationen
dc.subjectwhole exome sequencingen
dc.subjectanimalen
dc.subjectanimal venereal tumoren
dc.subjectclassificationen
dc.subjectclonal evolutionen
dc.subjectdogen
dc.subjectdog diseaseen
dc.subjectexosomeen
dc.subjectgenetic selectionen
dc.subjectgeneticsen
dc.subjectmutagenesisen
dc.subjectphylogenyen
dc.subjectAnimalsen
dc.subjectClonal Evolutionen
dc.subjectDog Diseasesen
dc.subjectDogsen
dc.subjectExosomesen
dc.subjectGene Expressionen
dc.subjectMutagenesisen
dc.subjectPhylogenyen
dc.subjectSelection, Geneticen
dc.subjectVenereal Tumors, Veterinaryen
dc.subjectAmerican Association for the Advancement of Scienceen
dc.titleSomatic evolution and global expansion of an ancient transmissible cancer lineageen
dc.typejournalArticleen


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