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Lipoprotein(a) is associated with large artery atherosclerosis stroke aetiology and stroke recurrence among patients below the age of 60 years: Results from the BIOSIGNAL study
dc.creator | Arnold M., Schweizer J., Nakas C.T., Schütz V., Westphal L.P., Inauen C., Pokorny T., Luft A., Leichtle A., Arnold M., Bicvic A., Fischer U., De Marchis G.M., Bonati L.H., Müller M.D., Kahles T., Nedeltchev K., Cereda C.W., Kägi G., Bustamante A., Montaner J., Ntaios G., Foerch C., Spanaus K., Von Eckardstein A., Katan M. | en |
dc.date.accessioned | 2023-01-31T07:33:12Z | |
dc.date.available | 2023-01-31T07:33:12Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.1093/eurheartj/ehab081 | |
dc.identifier.issn | 0195668X | |
dc.identifier.uri | http://hdl.handle.net/11615/70815 | |
dc.description.abstract | Aims: Lipoprotein(a) [Lp(a)] is a recognized causal risk factor for atherosclerotic cardiovascular disease but its role for acute ischaemic stroke (AIS) is controversial. In this study, we evaluated the association of Lp(a) with large artery atherosclerosis (LAA) stroke and risk of recurrent cerebrovascular events in AIS patients. Methods and results: For this analysis of the prospective, observational, multicentre BIOSIGNAL cohort study we measured Lp(a) levels in plasma samples of 1733 primarily Caucasian (98.6%) AIS patients, collected within 24 h after symptom onset. Primary outcomes were LAA stroke aetiology and recurrent cerebrovascular events (ischaemic stroke or transient ischaemic attack) within 1 year. We showed that Lp(a) levels are independently associated with LAA stroke aetiology [adjusted odds ratio 1.48, 95% confidence interval (CI) 1.14-1.90, per unit log10Lp(a) increase] and identified age as a potent effect modifier (Pinteraction =0.031) of this association. The adjusted odds ratio for LAA stroke in patients aged <60 years was 3.64 (95% CI 1.76-7.52) per unit log10Lp(a) increase and 4.04 (95% CI 1.73-9.43) using the established cut-off ≥100 nmol/l. For 152 recurrent cerebrovascular events, we did not find a significant association in the whole cohort. However, Lp(a) levels ≥100 nmol/l were associated with an increased risk for recurrent events among patients who were either <60 years [adjusted hazard ratio (HR) 2.40, 95% CI 1.05-5.47], had evident LAA stroke aetiology (adjusted HR 2.18, 95% CI 1.08-4.40), or had no known atrial fibrillation (adjusted HR 1.60, 95% CI 1.03-2.48). Conclusion: Elevated Lp(a) was independently associated with LAA stroke aetiology and risk of recurrent cerebrovascular events among primarily Caucasian individuals aged <60 years or with evident arteriosclerotic disease. © 2021 Published on behalf of the European Society of Cardiology. All rights reserved. | en |
dc.language.iso | en | en |
dc.source | European Heart Journal | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108021204&doi=10.1093%2feurheartj%2fehab081&partnerID=40&md5=221f9a859f2d4688619f6bc420a0696d | |
dc.subject | anticoagulant agent | en |
dc.subject | antihypertensive agent | en |
dc.subject | antilipemic agent | en |
dc.subject | antithrombocytic agent | en |
dc.subject | lipoprotein | en |
dc.subject | lipoprotein A | en |
dc.subject | adult | en |
dc.subject | aged | en |
dc.subject | area under the curve | en |
dc.subject | Article | en |
dc.subject | atrial fibrillation | en |
dc.subject | blood clot lysis | en |
dc.subject | brain atherosclerosis | en |
dc.subject | Caucasian | en |
dc.subject | cerebrovascular accident | en |
dc.subject | cohort analysis | en |
dc.subject | controlled study | en |
dc.subject | coronary artery atherosclerosis | en |
dc.subject | demography | en |
dc.subject | disease association | en |
dc.subject | disease classification | en |
dc.subject | disease marker | en |
dc.subject | dyslipidemia | en |
dc.subject | electrocardiography | en |
dc.subject | female | en |
dc.subject | genetic association | en |
dc.subject | human | en |
dc.subject | hypertension | en |
dc.subject | ischemic stroke | en |
dc.subject | limit of detection | en |
dc.subject | limit of quantitation | en |
dc.subject | magnetic resonance angiography | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | mechanical thrombectomy | en |
dc.subject | middle aged | en |
dc.subject | National Institutes of Health Stroke Scale | en |
dc.subject | observational study | en |
dc.subject | receiver operating characteristic | en |
dc.subject | recurrent disease | en |
dc.subject | risk assessment | en |
dc.subject | risk factor | en |
dc.subject | transesophageal echocardiography | en |
dc.subject | transient ischemic attack | en |
dc.subject | very elderly | en |
dc.subject | artery | en |
dc.subject | atherosclerosis | en |
dc.subject | brain ischemia | en |
dc.subject | cerebrovascular accident | en |
dc.subject | clinical trial | en |
dc.subject | complication | en |
dc.subject | multicenter study | en |
dc.subject | prospective study | en |
dc.subject | recurrent disease | en |
dc.subject | Arteries | en |
dc.subject | Atherosclerosis | en |
dc.subject | Brain Ischemia | en |
dc.subject | Cohort Studies | en |
dc.subject | Humans | en |
dc.subject | Lipoprotein(a) | en |
dc.subject | Middle Aged | en |
dc.subject | Prospective Studies | en |
dc.subject | Recurrence | en |
dc.subject | Risk Factors | en |
dc.subject | Stroke | en |
dc.subject | Oxford University Press | en |
dc.title | Lipoprotein(a) is associated with large artery atherosclerosis stroke aetiology and stroke recurrence among patients below the age of 60 years: Results from the BIOSIGNAL study | en |
dc.type | journalArticle | en |
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