dc.creator | Aristotelous P., Stefanakis M., Pantzaris M., Pattichis C.S., Calder P.C., Patrikios I.S., Sakkas G.K., Giannaki C.D. | en |
dc.date.accessioned | 2023-01-31T07:33:10Z | |
dc.date.available | 2023-01-31T07:33:10Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.3390/nu13103661 | |
dc.identifier.issn | 20726643 | |
dc.identifier.uri | http://hdl.handle.net/11615/70810 | |
dc.description.abstract | Patients with multiple sclerosis (MS) are characterized by, among other symptoms, impaired functional capacity and walking difficulties. Polyunsaturated fatty acids (PUFAs) have been found to improve MS patients’ clinical outcomes; however, their effect on other parameters associated with daily living activities need further investigation. The current study aimed to examine the effect of a 24-month supplementation with a cocktail dietary supplement formula, the Neuroaspis™ PLP10, containing specific omega-3 and omega-6 PUFAs and specific antioxidant vitamins on gait and functional capacity parameters of patients with MS. Fifty-one relapsing-remitting MS (RRMS) patients with low disability scores (age: 38.4 ± 7.1 years; 30 female) were randomized 1:1 to receive either a 20 mL daily dose of the dietary formula containing a mixture of omega-3 and omega-6 PUFAs (12,150 mg), vitamin A (0.6 mg), vitamin E (22 mg), and γ-tocopherol (760 mg), the OMEGA group (n = 27; age: 39 ± 8.3 years), or 20 mL placebo containing virgin olive oil, the placebo group (n = 24; age: 37.8 ± 5.3 years). The mean ± SD (standard deviation) Expanded Disability Status Scale (EDSS) score for the placebo group was 2.36 and for the OMEGA group 2.22. All enrolled patients in the study were on Interferon-β treatment. Spatiotemporal gait parameters and gait deviation index (GDI) were assessed using a motion capture system. Functional capacity was examined using various functional tests such as the six-minute walk test (6MWT), two sit-to-stand tests (STS-5 and STS-60), and the Timed Up and Go test (TUG). Isometric handgrip strength was assessed by a dynamometer. Leg strength was assessed using an isokinetic dynamometer. All assessments were performed at baseline and at 12 and 24 months of supplementation. A total of 36 patients completed the study (18 from each group). Six patients from the placebo group and 9 patients from the OMEGA group dropped out from the study or were lost to follow-up. The dietary supplement significantly improved the single support time and the step and stride time (p < 0.05), both spatiotemporal gait parameters. In addition, while GDI of the placebo group decreased by about 10% at 24 months, it increased by about 4% in the OMEGA group (p < 0.05). Moreover, performance in the STS-60 test improved in the OMEGA group (p < 0.05) and there was a tendency for improvement in the 6MWT and TUG tests. Long-term supplementation with high dosages of omega-3 and omega-6 PUFAs (compared to previous published clinical studies using PUFAs) and specific antioxidant vitamins improved some functional capacity and gait parameters in RRMS patients. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.language.iso | en | en |
dc.source | Nutrients | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117222110&doi=10.3390%2fnu13103661&partnerID=40&md5=9f1dd16b0eb59611ae22da0433b72cca | |
dc.subject | alpha tocopherol | en |
dc.subject | gamma tocopherol | en |
dc.subject | omega 3 fatty acid | en |
dc.subject | omega 6 fatty acid | en |
dc.subject | placebo | en |
dc.subject | recombinant beta interferon | en |
dc.subject | retinol | en |
dc.subject | virgin olive oil | en |
dc.subject | antioxidant | en |
dc.subject | omega 3 fatty acid | en |
dc.subject | omega 6 fatty acid | en |
dc.subject | vitamin | en |
dc.subject | adult | en |
dc.subject | anthropometry | en |
dc.subject | Article | en |
dc.subject | body composition | en |
dc.subject | clinical outcome | en |
dc.subject | controlled study | en |
dc.subject | daily life activity | en |
dc.subject | diet supplementation | en |
dc.subject | dietary supplement | en |
dc.subject | double blind procedure | en |
dc.subject | drug megadose | en |
dc.subject | Expanded Disability Status Scale | en |
dc.subject | female | en |
dc.subject | follow up | en |
dc.subject | functional status | en |
dc.subject | gait | en |
dc.subject | gait disorder | en |
dc.subject | grip strength | en |
dc.subject | human | en |
dc.subject | major clinical study | en |
dc.subject | male | en |
dc.subject | multiple sclerosis | en |
dc.subject | randomized controlled trial | en |
dc.subject | six minute walk test | en |
dc.subject | spatiotemporal analysis | en |
dc.subject | task performance | en |
dc.subject | timed up and go test | en |
dc.subject | drug effect | en |
dc.subject | gait | en |
dc.subject | hand strength | en |
dc.subject | knee | en |
dc.subject | multiple sclerosis | en |
dc.subject | pathophysiology | en |
dc.subject | physiology | en |
dc.subject | time factor | en |
dc.subject | Adult | en |
dc.subject | Antioxidants | en |
dc.subject | Body Composition | en |
dc.subject | Fatty Acids, Omega-3 | en |
dc.subject | Fatty Acids, Omega-6 | en |
dc.subject | Female | en |
dc.subject | Gait | en |
dc.subject | Hand Strength | en |
dc.subject | Humans | en |
dc.subject | Knee | en |
dc.subject | Male | en |
dc.subject | Multiple Sclerosis, Relapsing-Remitting | en |
dc.subject | Time Factors | en |
dc.subject | Vitamins | en |
dc.subject | MDPI | en |
dc.title | The effects of specific omega-3 and omega-6 polyunsaturated fatty acids and antioxidant vitamins on gait and functional capacity parameters in patients with relapsing-remitting multiple sclerosis | en |
dc.type | journalArticle | en |