Bayesian estimation of sensitivity and specificity of a commercial serum/milk ELISA against the Mycobacterium avium subsp. Paratuberculosis (MAP) antibody response for each lactation stage in Greek dairy sheep
dc.creator | Angelidou E., Kostoulas P., Leontides L. | en |
dc.date.accessioned | 2023-01-31T07:31:50Z | |
dc.date.available | 2023-01-31T07:31:50Z | |
dc.date.issued | 2016 | |
dc.identifier | 10.1016/j.prevetmed.2015.12.011 | |
dc.identifier.issn | 01675877 | |
dc.identifier.uri | http://hdl.handle.net/11615/70619 | |
dc.description.abstract | A total of 854 paired milk and blood samples were collected from ewes of a Greek flock and used to estimate the sensitivity and specificity of a commercial ELISA for detection of Mycobacterium avium subsp. paratuberculosis (MAP) specific antibodies in each stage of lactation. We implemented Bayesian mixture models to derive the distributions of the test response for the healthy and the infected ewes. In the colostrum period, early, mid and late lactation stage the median values of the area under the curves (AUC) were 0.61 (95% credible interval: 0.50; 0.84), 0.61 (0.51;0.84), 0.65 (0.51;0.91), 0.65(0.51;0.89) for the serum ELISA and and 0.60 (0.50; 0.84), 0.61 (0.50; 0.84), 0.67(0.51; 0.91), 0.66(0.50; 0.90) for the milk ELISA, respectively. Both serum and milk ELISA had low to average overall discriminatory ability as measured by the area under the curves and comparable sensitivities and specificities at the recommended cutoffs. © 2015 Elsevier B.V.. | en |
dc.language.iso | en | en |
dc.source | Preventive Veterinary Medicine | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84954392721&doi=10.1016%2fj.prevetmed.2015.12.011&partnerID=40&md5=8594891e95163ef030cc9317c5c94f3f | |
dc.subject | bacterium antibody | en |
dc.subject | animal | en |
dc.subject | Bayes theorem | en |
dc.subject | blood | en |
dc.subject | dairying | en |
dc.subject | enzyme linked immunosorbent assay | en |
dc.subject | female | en |
dc.subject | Greece | en |
dc.subject | isolation and purification | en |
dc.subject | lactation | en |
dc.subject | microbiology | en |
dc.subject | milk | en |
dc.subject | Mycobacterium avium subsp. paratuberculosis | en |
dc.subject | paratuberculosis | en |
dc.subject | procedures | en |
dc.subject | sensitivity and specificity | en |
dc.subject | serum | en |
dc.subject | sheep | en |
dc.subject | Sheep Diseases | en |
dc.subject | veterinary | en |
dc.subject | Animals | en |
dc.subject | Antibodies, Bacterial | en |
dc.subject | Bayes Theorem | en |
dc.subject | Dairying | en |
dc.subject | Enzyme-Linked Immunosorbent Assay | en |
dc.subject | Female | en |
dc.subject | Greece | en |
dc.subject | Lactation | en |
dc.subject | Milk | en |
dc.subject | Mycobacterium avium subsp. paratuberculosis | en |
dc.subject | Paratuberculosis | en |
dc.subject | Sensitivity and Specificity | en |
dc.subject | Serum | en |
dc.subject | Sheep | en |
dc.subject | Sheep Diseases | en |
dc.subject | Elsevier | en |
dc.title | Bayesian estimation of sensitivity and specificity of a commercial serum/milk ELISA against the Mycobacterium avium subsp. Paratuberculosis (MAP) antibody response for each lactation stage in Greek dairy sheep | en |
dc.type | journalArticle | en |
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