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Ranolazine depresses conduction of rapid atrial depolarizations in a beating rabbit heart model
dc.creator | Aidonidis I., Simopoulos V., Stravela S., Dipla K., Stamatiou R., Hatziefthimiou A., Molyvdas P.-A. | en |
dc.date.accessioned | 2023-01-31T07:30:35Z | |
dc.date.available | 2023-01-31T07:30:35Z | |
dc.date.issued | 2021 | |
dc.identifier | 10.1007/s10840-020-00865-0 | |
dc.identifier.issn | 1383875X | |
dc.identifier.uri | http://hdl.handle.net/11615/70341 | |
dc.description.abstract | Purpose: Previous clinical studies have shown that ranolazine (RAN) added to amiodarone (AMIO) might accelerate the termination of recent-onset atrial fibrillation. This study was undertaken to delineate possible mechanisms that contribute to the enhancement of the antiarrhythmic efficacy of RAN-AMIO coadministration. Methods: Ten rabbits were anesthetized and two monophasic action potential (MAP) catheters were sequentially inserted into the right atrium. One MAP electrode was used to pace and record; the other electrode was used only for recording MAP from an adjacent atrial region. Intraatrial conduction time (IACT), 2:1 intraatrial conduction block (IACB), and atrial post-repolarization refractoriness (aPRR) were consecutively determined by high-rate atrial burst pacing and programmed stimulation, respectively. All parameters were evaluated during baseline and following AMIO (3 mg/kg iv) or AMIO+RAN (2.4 mg/kg iv bolus +0.134 mg/kg/min maintenance infusion). Results: The IACT remained unchanged post AMIO compared with baseline (37.6 ± 3.8 vs 36.4 ± 2.4 ms), whereas the addition of RAN to AMIO significantly prolonged IACT (50.4 ± 3.6 ms, p <.001). The pacing cycle length producing 2:1 IACB was 101.2 ± 21.7 ms at baseline , 117.5 ± 15 ms after AMIO (p = 0.265), and 150 ± 14 ms after AMIO+RAN (p <.001). Baseline aPRR was longer following AMIO treatment (35 ± 5 vs 50 ± 9 ms, p <.01) but remarkably prolonged with RAN supplementation (105 ± 11 ms, p <.001). Conclusions: RAN significantly prolonged the propagation time of rapid atrial depolarizations and potentiated the AMIO-induced moderate increases in aPRR. These mechanisms possibly contribute to the earlier termination of atrial fibrillation when RAN is co-administered with AMIO. © 2020, Springer Science+Business Media, LLC, part of Springer Nature. | en |
dc.language.iso | en | en |
dc.source | Journal of Interventional Cardiac Electrophysiology | en |
dc.source.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091726556&doi=10.1007%2fs10840-020-00865-0&partnerID=40&md5=9a21a27ba9a7653d50667cb16ceb6613 | |
dc.subject | amiodarone | en |
dc.subject | ranolazine | en |
dc.subject | amiodarone | en |
dc.subject | antiarrhythmic agent | en |
dc.subject | ranolazine | en |
dc.subject | action potential | en |
dc.subject | animal experiment | en |
dc.subject | animal model | en |
dc.subject | antiarrhythmic activity | en |
dc.subject | Article | en |
dc.subject | atrial depolarization | en |
dc.subject | atrial fibrillation | en |
dc.subject | cardiovascular response | en |
dc.subject | controlled study | en |
dc.subject | drug efficacy | en |
dc.subject | drug potentiation | en |
dc.subject | drug response | en |
dc.subject | heart atrium conduction | en |
dc.subject | heart atrium pacing | en |
dc.subject | heart beat | en |
dc.subject | heart depolarization | en |
dc.subject | heart repolarization | en |
dc.subject | nonhuman | en |
dc.subject | supraventricular tachycardia | en |
dc.subject | animal | en |
dc.subject | atrial fibrillation | en |
dc.subject | heart rate | en |
dc.subject | Leporidae | en |
dc.subject | Action Potentials | en |
dc.subject | Amiodarone | en |
dc.subject | Animals | en |
dc.subject | Anti-Arrhythmia Agents | en |
dc.subject | Atrial Fibrillation | en |
dc.subject | Heart Rate | en |
dc.subject | Rabbits | en |
dc.subject | Ranolazine | en |
dc.subject | Springer | en |
dc.title | Ranolazine depresses conduction of rapid atrial depolarizations in a beating rabbit heart model | en |
dc.type | journalArticle | en |
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