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Primary biliary cirrhosis-specific autoantibodies in first degree relatives of Greek primary biliary cirrhosis patients
dc.creator | Zografos, T. A. | en |
dc.creator | Gatselis, N. | en |
dc.creator | Zachou, K. | en |
dc.creator | Liaskos, C. | en |
dc.creator | Gabeta, S. | en |
dc.creator | Koukoulis, G. K. | en |
dc.creator | Dalekos, G. N. | en |
dc.date.accessioned | 2015-11-23T10:55:24Z | |
dc.date.available | 2015-11-23T10:55:24Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.3748/wjg.v18.i34.4721 | |
dc.identifier.issn | 1007-9327 | |
dc.identifier.uri | http://hdl.handle.net/11615/35016 | |
dc.description.abstract | AIM: To determine the prevalence and significance of primary biliary cirrhosis (PBC)-specific autoantibodies in first-degree relatives (FDRS) of Greek PBC patients. METHODS: The presence of antimitochondrial antibodies (AMA) and PBC-specific antinuclear antibodies (ANA) were determined using indirect immunofluorescence assays, dot-blot assays, and molecularly based enzyme-linked immunosorbent assays in 101 asymptomatic for liver-related symptoms FDRs of 44 PBC patients. In order to specify our results, the same investigation was performed in 40 healthy controls and in a disease control group consisting of 40 asymptomatic for liver-related symptoms FDRs of patients with other autoimnnune liver diseases namely, autoimmune hepatitis-1 or primary sclerosing cholangitis (AIH-1/PSC). RESULTS: AMA positivity was observed in 19 (only 4 with abnormal liver function tests) FDRs of PBC patients and none of the healthy controls. The prevalence of AMA was significantly higher in FDRs of PBC patients than in AIH-1/PSC FDRs and healthy controls [18.8%, 95% confidence interval (CI): 12%-28.1% VS 2.5%, 95% CI: 0.1%-14.7%, P = 0.01; 18.8%, 95% CI: 12%-28.1% VS 0%, 95% CI: 0%-10.9%, P = 0.003, respectively]. PBC-specific ANA positivity was observed in only one FDR from a PSC patient. Multivariate analysis showed that having a proband with PBC independently associated with AMA positivity (odds ratio: 11.24, 95% CI: 1.27-25.34, P = 0.03) whereas among the investigated comorbidities and risk factors, a positive past history for urinary tract infections (UT!) was also independently associated with AMA detection in FDRs of PBC patients (odds ratio: 3.92, 95% CI: 1.25-12.35, P = 0.02). CONCLUSION: In FDRs of Greek PBC patients, AMA prevalence is significantly increased and independently associated with past UTI. PBC-specific ANA were not detected in anyone of PBC FDRs. (C) 2012 Baishideng. All rights reserved. | en |
dc.source | World Journal of Gastroenterology | en |
dc.source.uri | <Go to ISI>://WOS:000308895300011 | |
dc.subject | Primary biliary cirrhosis | en |
dc.subject | Antimitochondrial antibodies | en |
dc.subject | Anti-gp210 | en |
dc.subject | Anti-sp100 | en |
dc.subject | Liver autoimmunity | en |
dc.subject | AUTOIMMUNE HEPATITIS TYPE-1 | en |
dc.subject | ANTIMITOCHONDRIAL ANTIBODIES | en |
dc.subject | ANTINUCLEAR | en |
dc.subject | ANTIBODIES | en |
dc.subject | CLINICAL-SIGNIFICANCE | en |
dc.subject | URSODEOXYCHOLIC ACID | en |
dc.subject | FAMILIAL | en |
dc.subject | DISEASE | en |
dc.subject | NATURAL-HISTORY | en |
dc.subject | HIGH PREVALENCE | en |
dc.subject | RISK-FACTORS | en |
dc.subject | POPULATION | en |
dc.subject | Gastroenterology & Hepatology | en |
dc.title | Primary biliary cirrhosis-specific autoantibodies in first degree relatives of Greek primary biliary cirrhosis patients | en |
dc.type | journalArticle | en |
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