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Performance of antibodies against tissue transglutaminase for the diagnosis of Celiac disease: Meta-analysis
dc.creator | Zintzaras, E. | en |
dc.creator | Germenis, A. E. | en |
dc.date.accessioned | 2015-11-23T10:55:09Z | |
dc.date.available | 2015-11-23T10:55:09Z | |
dc.date.issued | 2006 | |
dc.identifier | 10.1128/cvi.13.2.187-192.2006 | |
dc.identifier.issn | 1556-6811 | |
dc.identifier.uri | http://hdl.handle.net/11615/34943 | |
dc.description.abstract | A meta-analysis of studies investigating the diagnostic accuracy of enzyme-linked immunosorbent assays (ELISA) for antibodies against tissue transglutaminases (tTG) of various origins in celiac disease (CD) diagnosis was carried out. Twenty-one studies, with untreated CD patients and healthy/CD-free controls, were included in the meta-analysis. The diagnostic accuracy was estimated using a summary receiver operating characteristic (SROC) curve and pooled sensitivity (Se) and specificity (Sp). Multiple assays within a study were treated by considering all the assays within a study and by analyzing the most popular assay (i.e., the commercial anti-tTTG ELISA most frequently utilized in the papers in which multiple assays were included). The SROC curve indicated the absence of heterogeneity, and the superiority of recombinant human tTG (rh-tTG) and purified human tTG (ph-tTG) compared to guinea pig-tTG (gp-tTG). The sensitivities (most popular assay) for rh-tTG, ph-tTG, and gp-tTG were 94%, 90%, and 92%, respectively, and the specificities were 97%, 92%, and 96%, respectively. A sensitivity analysis (exclusion of studies with bias) altered the results of ph-tTG: Se, 95%; Sp, 98%. The sensitivities (all individual assays) for rh-tTG, ph-tTG, and gp-tTG were 94%, 94%, and 91%, respectively, and the specificities were 95%, 94%, and 89%, respectively. Human tTG ELISA is sensitive and specific, and it can be used for mass screening. Sensitivity analysis showed that ph-tTG might perform better. | en |
dc.source.uri | <Go to ISI>://WOS:000235539300004 | |
dc.subject | FOLLOW-UP | en |
dc.subject | GUINEA-PIG | en |
dc.subject | ENDOMYSIAL ANTIBODIES | en |
dc.subject | INTESTINAL BIOPSY | en |
dc.subject | CLINICAL-PRACTICE | en |
dc.subject | ASSAY | en |
dc.subject | TESTS | en |
dc.subject | ELISA | en |
dc.subject | CHILDREN | en |
dc.subject | ADULTS | en |
dc.subject | Immunology | en |
dc.subject | Infectious Diseases | en |
dc.subject | Microbiology | en |
dc.title | Performance of antibodies against tissue transglutaminase for the diagnosis of Celiac disease: Meta-analysis | en |
dc.type | journalArticle | en |
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