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Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis
dc.creator | Zintzaras, E. | en |
dc.date.accessioned | 2015-11-23T10:55:04Z | |
dc.date.available | 2015-11-23T10:55:04Z | |
dc.date.issued | 2006 | |
dc.identifier | 10.1007/s10038-006-0405-6 | |
dc.identifier.issn | 1434-5161 | |
dc.identifier.uri | http://hdl.handle.net/11615/34919 | |
dc.description.abstract | To clarify the influence of MTHFR C677T and A1298C polymorphisms on gastric cancer (GC), a meta-analysis of eight case-control studies (1,584/2,785 cases/controls) was carried out. Overall, there was moderate heterogeneity among studies, and the C677T allele T was associated with a 27% increased risk of GC compared with C allele: the random effects (RE) OR (95% confidence interval in parenthesis) was significant [OR = 1.27 (1.13-1.44)]. In East Asians, the association was significant: RE OR = 1.28 (1.14-1.44), whereas, in Caucasians it was not significant. Regarding gastric cancer adenocarcinoma (GCA), an association for the allele contrast in East Asians was detected: fixed effects (FE) OR = 1.36 (1.18-1.56). The recessive model for allele T produced significant results overall and in East Asians for GC [FE OR = 1.47 (1.26-1.72) and FE OR = 1.61 (1.32-1.96), respectively] and for GCA [RE OR = 1.53 (1.13-2.05) and FE OR = 1.70 (1.36-2.12)]. The A1298C polymorphism was associated with GCA in East Asians: the FE OR for the allele contrast (C vs. A) was 1.38 (1.18-1.62), and under a recessive model for allele C, OR = 1.62 (1.28-2.06). There were no sources of bias in the selected studies; the differential magnitude effect in large versus small studies was not significant. In conclusion, there is evidence of association between MTHFR polymorphisms and GC, mainly in East Asians. | en |
dc.source.uri | <Go to ISI>://WOS:000239168200006 | |
dc.subject | gastric cancer | en |
dc.subject | MTHFR | en |
dc.subject | C677T | en |
dc.subject | A1298C | en |
dc.subject | meta-analysis | en |
dc.subject | CHINESE POPULATION | en |
dc.subject | 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE | en |
dc.subject | CUMULATIVE | en |
dc.subject | METAANALYSIS | en |
dc.subject | PARKINSONS-DISEASE | en |
dc.subject | C677T POLYMORPHISM | en |
dc.subject | CARDIA CANCER | en |
dc.subject | RISK | en |
dc.subject | ESOPHAGEAL | en |
dc.subject | FOLATE | en |
dc.subject | ADENOCARCINOMA | en |
dc.subject | Genetics & Heredity | en |
dc.title | Association of methylenetetrahydrofolate reductase (MTHFR) polymorphisms with genetic susceptibility to gastric cancer: a meta-analysis | en |
dc.type | journalArticle | en |
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