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dc.creatorZafiropoulos, A.en
dc.creatorTsarouhas, K.en
dc.creatorTsitsimpikou, C.en
dc.creatorFragkiadaki, P.en
dc.creatorGermanakis, I.en
dc.creatorTsardi, M.en
dc.creatorMaravgakis, G.en
dc.creatorGoutzourelas, N.en
dc.creatorVasilaki, F.en
dc.creatorKouretas, D.en
dc.creatorHayes, A. W.en
dc.creatorTsatsakis, A. M.en
dc.date.accessioned2015-11-23T10:54:39Z
dc.date.available2015-11-23T10:54:39Z
dc.date.issued2014
dc.identifier10.1177/0960327114532384
dc.identifier.issn0960-3271
dc.identifier.urihttp://hdl.handle.net/11615/34798
dc.description.abstractLethal cardiac complications leading to death and various arrhythmias have been reported after organophosphate and/or carbamate poisonings. The present study focuses on the long-term effects of repeated low-level exposure to diazinon, propoxur, and chlorpyrifos (CPF) on cardiac function in rabbits. The yearly based experimental scheme of exposure consisted of two oral administration periods, lasting 3 months and I month each, interrupted by an 8-month washout period (total duration 12 months). At the end of the experimental scheme, the rabbits underwent an echocardiographic evaluation under sedation, after which they were killed and the tissue and serum samples were collected. A mild localized cardiotoxic effect was established by echocardiography for the three pesticides tested. Severe histological alterations were identified, especially in the diazinon-treated animals in agreement with increased persistence of this pesticide established in the cardiac tissue. In addition, all pesticides tested increased the oxidative stress and oxidative modifications in the genomic DNA content of the cardiac tissues, each one following a distinct mechanism.en
dc.sourceHuman & Experimental Toxicologyen
dc.source.uri<Go to ISI>://WOS:000345878700006
dc.subjectPropoxuren
dc.subjectdiazinonen
dc.subjectchlorpyrifosen
dc.subjectcardiac dysfunctionen
dc.subjectOXIDATIVE STRESSen
dc.subjectTELOMERASE ACTIVITYen
dc.subjectORGANOPHOSPHORUS INSECTICIDESen
dc.subjectIN-VITROen
dc.subjectM-MODEen
dc.subjectRATSen
dc.subjectCELLSen
dc.subjectDAMAGEen
dc.subjectINJURYen
dc.subjectLIVERen
dc.subjectToxicologyen
dc.titleCardiotoxicity in rabbits after a low-level exposure to diazinon, propoxur, and chlorpyrifosen
dc.typejournalArticleen


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