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Role of vitamin C and E supplementation on IL-6 in response to training
dc.creator | Yfanti, C. | en |
dc.creator | Fischer, C. P. | en |
dc.creator | Nielsen, S. | en |
dc.creator | Akerstrom, T. | en |
dc.creator | Nielsen, A. R. | en |
dc.creator | Veskoukis, A. S. | en |
dc.creator | Kouretas, D. | en |
dc.creator | Lykkesfeldt, J. | en |
dc.creator | Pilegaard, H. | en |
dc.creator | Pedersen, B. K. | en |
dc.date.accessioned | 2015-11-23T10:54:25Z | |
dc.date.available | 2015-11-23T10:54:25Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.1152/japplphysiol.01027.2010 | |
dc.identifier.issn | 8750-7587 | |
dc.identifier.uri | http://hdl.handle.net/11615/34733 | |
dc.description.abstract | Yfanti C, Fischer CP, Nielsen S, Akerstrom T, Nielsen AR, Veskoukis AS, Kouretas D, Lykkesfeldt J, Pilegaard H, Pedersen BK. Role of vitamin C and E supplementation on IL-6 in response to training. J Appl Physiol 112: 990-1000, 2012. First published December 29, 2011; doi: 10.1152/japplphysiol.01027.2010.-Vitamin C and E supplementation has been shown to attenuate the acute exercise-induced increase in plasma interleukin-6 (IL-6) concentration. Here, we studied the effect of antioxidant vitamins on the regulation of IL-6 expression in muscle and the circulation in response to acute exercise before and after high-intensity endurance exercise training. Twenty-one young healthy men were allocated into either a vitamin (VT; vitamin C and E, n = 11) or a placebo (PL, n = 10) group. A 1-h acute bicycling exercise trial at 65% of maximal power output was performed before and after 12 wk of progressive endurance exercise training. In response to training, the acute exercise-induced IL-6 response was attenuated in PL (P < 0.02), but not in VT (P = 0.82). However, no clear difference between groups was observed (group x training: P = 0.13). Endurance exercise training also attenuated the acute exercise-induced increase in muscle-IL-6 mRNA in both groups. Oxidative stress, assessed by plasma protein carbonyls concentration, was overall higher in the VT compared with the PL group (group effect: P < 0.005). This was accompanied by a general increase in skeletal muscle mRNA expression of antioxidative enzymes, including catalase, copper-zinc superoxide dismutase, and glutathione peroxidase 1 mRNA expression in the VT group. However, skeletal muscle protein content of catalase, copper-zinc superoxide dismutase, or glutathione peroxidase 1 was not affected by training or supplementation. In conclusion, our results indicate that, although vitamin C and E supplementation may attenuate exercise-induced increases in plasma IL-6 there is no clear additive effect when combined with endurance training. | en |
dc.source | Journal of Applied Physiology | en |
dc.source.uri | <Go to ISI>://WOS:000302535900008 | |
dc.subject | vitamin C | en |
dc.subject | vitamin E | en |
dc.subject | endurance exercise | en |
dc.subject | interleukin-6 | en |
dc.subject | HUMAN SKELETAL-MUSCLE | en |
dc.subject | MESSENGER-RNA EXPRESSION | en |
dc.subject | EXERCISE-INDUCED | en |
dc.subject | INCREASE | en |
dc.subject | LIPID-PEROXIDATION | en |
dc.subject | OXIDATIVE STRESS | en |
dc.subject | ADAPTIVE RESPONSE | en |
dc.subject | SUPEROXIDE-DISMUTASE | en |
dc.subject | INFLAMMATORY MARKERS | en |
dc.subject | CYTOKINE RESPONSE | en |
dc.subject | PHYSICAL-ACTIVITY | en |
dc.subject | Physiology | en |
dc.subject | Sport Sciences | en |
dc.title | Role of vitamin C and E supplementation on IL-6 in response to training | en |
dc.type | journalArticle | en |
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