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CD10 Is Inversely Associated with Nuclear Factor-Kappa B and Predicts Biochemical Recurrence after Radical Prostatectomy
dc.creator | Voutsadakis, I. A. | en |
dc.creator | Vlachostergios, P. J. | en |
dc.creator | Daliani, D. D. | en |
dc.creator | Karasavvidou, F. | en |
dc.creator | Kakkas, G. | en |
dc.creator | Moutzouris, G. | en |
dc.creator | Melekos, M. D. | en |
dc.creator | Papandreou, C. N. | en |
dc.date.accessioned | 2015-11-23T10:54:04Z | |
dc.date.available | 2015-11-23T10:54:04Z | |
dc.date.issued | 2012 | |
dc.identifier | 10.1159/000335299 | |
dc.identifier.issn | 0042-1138 | |
dc.identifier.uri | http://hdl.handle.net/11615/34642 | |
dc.description.abstract | Introduction: The cell surface endopeptidase CD10 (neutral endopeptidase) and nuclear factor-kappa B (NF-kappa B) have been independently associated with prostate cancer (PC) progression. We investigated the correlations between these two factors and their prognostic relevance in terms of biochemical (prostate-specific antigen, PSA) relapse after radical prostatectomy (RP) for localized PC. Patients and Methods: The immunohistochemical expression of CD10 and NF-kappa B in samples from 70 patients who underwent RP for localized PC was correlated with the preoperative PSA level, Gleason score, pathological stage and time to PSA failure. Results: CD10 expression was inversely associated with NF-kappa B expression (p < 0.001), stage (p = 0.03) and grade (p = 0.003), whereas NF-kappa B was directly related with stage (p = 0.006) and grade (p = 0.002). The median time to PSA failure was 56 months. CD10 and NF-kappa B were directly (p < 0.001) and inversely (p < 0.001) correlated with biochemical recurrence-free survival, respectively. CD10 expression (p = 0.022) and stage (p = 0.018) were independently associated with time to biochemical recurrence. Conclusion: Low CD10 expression is an adverse prognostic factor for biochemical relapse after RP in localized PC, which is also associated with high NF-kappa B expression. Decreased CD10 expression which would lead to increased neuropeptide signaling and NF-kappa B activity may be present in a subset of early PCs. Copyright (C) 2012 S. Karger AG, Basel | en |
dc.source.uri | <Go to ISI>://WOS:000302134800005 | |
dc.subject | CD10 | en |
dc.subject | Nuclear factor-kappa B | en |
dc.subject | Prostate-specific antigen relapse | en |
dc.subject | Prostate cancer | en |
dc.subject | NEUTRAL ENDOPEPTIDASE | en |
dc.subject | PROGNOSTIC-SIGNIFICANCE | en |
dc.subject | ENDOTHELIN AXIS | en |
dc.subject | CANCER | en |
dc.subject | PROGRESSION | en |
dc.subject | EXPRESSION | en |
dc.subject | LOCALIZATION | en |
dc.subject | ACTIVATION | en |
dc.subject | PATHWAY | en |
dc.subject | Urology & Nephrology | en |
dc.title | CD10 Is Inversely Associated with Nuclear Factor-Kappa B and Predicts Biochemical Recurrence after Radical Prostatectomy | en |
dc.type | journalArticle | en |
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