| dc.description.abstract | Background: Assessment of breast lesions with magnetic resonance imaging (MRI) provides a means for lesion detection and diagnosis. Proton (hydrogen-1) magnetic resonance spectroscopy (H-1-MRS) has been proposed as a useful diagnostic technique in providing metabolic information of suspicious breast lesions. Purpose: To determine the clinical significance of in-vivo single voxel H-1-MRS at 3T in the assessment of benign and malignant breast lesions in combination with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Material and Methods: Twenty-four women with known breast abnormalities from conventional imaging (mammography, ultrasonography) underwent DCE-MRI at a 3T MR scanner and 26 breast lesions were detected. Breast lesions were assessed according BI-RADS classification. Single voxel H-1-MRS was performed after gadolinium administration and choline peak was qualitatively evaluated. All lesions were confirmed histologically from the surgically excised specimens. Sensitivity, specificity, and accuracy of the H-1-MRS, of the BI-RADS classification and of their combination (DCE-MRI + H-1-MRS) were calculated. Results: Fifteen out of 26 lesions proved to be malignant and 11 proved to be benign. In our study H-1-MRS showed sensitivity 80%, specificity 81.8%, and accuracy 80.7%. DCE-MRI showed sensitivity 100%, specificity 63.6%, and accuracy 84.6%. The combination of DCE-MRI and H-1-MRS provided higher accuracy (96.4%), as well as higher specificity 81.8% compared to BI-RADS classification. Conclusion: The combined use of H-1-MRS and DCE-MRI found to have improved diagnostic performance in the assessment of equivocal breast lesions. H-1-MRS can be used as a useful adjunct during lesion characterization in clinical routine in cases classified as BI-RADS 3 and 4. | en |
