Mismatch DNA repair mRNA expression profiles in oral melanin pigmentation lesion and hamartomatous polyp of a child with peutz-jeghers syndrome

dc.creator	Vageli, D. P.	en
dc.creator	Doukas, S. G.	en
dc.creator	Markou, A.	en
dc.date.accessioned	2015-11-23T10:53:02Z
dc.date.available	2015-11-23T10:53:02Z
dc.date.issued	2013
dc.identifier	10.1002/pbc.24579
dc.identifier.issn	1545-5009
dc.identifier.uri	http://hdl.handle.net/11615/34218
dc.description.abstract	Mismatch DNA repair (MMR) mRNA expression analysis was performed on a biopsy of oral mucosa melanin pigmentation lesion, a hamartomatous polyp and peripheral blood derived from a 12-year-old child with Peutz-Jeghers Syndrome (PJS). We present a deficient MMR system, in a PJS patient, which demonstrated low mRNA levels of hMSH6 and hPMS2 and an increasing MMR deficiency from the non-dysplastic lesion to hamartomatous polyp of PJS with a high risk of cancer. Pediatr Blood Cancer 2013;60:E116-E117. (c) 2013 Wiley Periodicals, Inc.	en
dc.source	Pediatric Blood & Cancer	en
dc.source.uri	<Go to ISI>://WOS:000322885200002
dc.subject	Peutz-Jeghers Syndrome	en
dc.subject	hMSH2	en
dc.subject	hMLH1	en
dc.subject	hMSH6	en
dc.subject	hPMS2	en
dc.subject	Q-RT-reall time-PCR	en
dc.subject	MUTATIONS	en
dc.subject	CANCER	en
dc.subject	Oncology	en
dc.subject	Hematology	en
dc.subject	Pediatrics	en
dc.title	Mismatch DNA repair mRNA expression profiles in oral melanin pigmentation lesion and hamartomatous polyp of a child with peutz-jeghers syndrome	en
dc.type	journalArticle	en

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