dc.creator | Ulukaya, E. | en |
dc.creator | Ari, F. | en |
dc.creator | Dimas, K. | en |
dc.creator | Sarimahmut, M. | en |
dc.creator | Guney, E. | en |
dc.creator | Sakellaridis, N. | en |
dc.creator | Yilmaz, V. T. | en |
dc.date.accessioned | 2015-11-23T10:52:59Z | |
dc.date.available | 2015-11-23T10:52:59Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.1007/s00432-011-1021-1 | |
dc.identifier.issn | 0171-5216 | |
dc.identifier.uri | http://hdl.handle.net/11615/34198 | |
dc.description.abstract | Purpose Treatment for lung cancer is still far from satisfying rates. Therefore, there is a need for novel anticancer agents. For this purpose, novel platinum and palladium complexes {[Pd(sac)(terpy)](sac).4H(2)O (Complex 1), [Pt(sac)(terpy)] (sac).5H(2)O (Complex 2), [PdCl(terpy)](sac).2H(2)O (Complex 3), [PtCl(terpy)](sac).2H(2)O (Complex 4)} have been tested against three different non-small cell lung cancer cell lines (A549, H1299, PC-3). Methods Growth-inhibiting effcts have been tested by the MTT and ATP viability assays. Apoptosis has been detected by the caspase-cleaved cytokeratin 18 (M30-antigen) assay. Necrosis has been detected by staining the cells with fluorescent dyes. Mitotic index has been calculated by counting the mitotic figures after staining with hematoxylin. Results The complex 3 exhibited significant anti-growth effects, and its anti-growth effect was more powerful than that of cisplatin that is a standard chemotherapeutic agent for this type of cancer. The complexes did not induce apoptosis, while necrosis clearly took place. Conclusions Novel Pd(II) complex ([PdCl(terpy)] (sac).2H(2)O) seems to represent a potentially active drug against non-small cell lung cancer cell lines, and further studies in vivo are warranted. | en |
dc.source | Journal of Cancer Research and Clinical Oncology | en |
dc.source.uri | <Go to ISI>://WOS:000295988800003 | |
dc.subject | Lung cancer treatment | en |
dc.subject | Palladium(II) and platinum(II) complexes | en |
dc.subject | Necrosis | en |
dc.subject | CYTOTOXIC ACTIVITY | en |
dc.subject | CRYSTAL-STRUCTURE | en |
dc.subject | ANTITUMOR AGENTS | en |
dc.subject | CISPLATIN | en |
dc.subject | PD(II) | en |
dc.subject | DNA | en |
dc.subject | APOPTOSIS | en |
dc.subject | PT(II) | en |
dc.subject | ASSAY | en |
dc.subject | HEPATOTOXICITY | en |
dc.subject | Oncology | en |
dc.title | Cell death-inducing effect of novel palladium(II) and platinum(II) complexes on non-small cell lung cancer cells in vitro | en |
dc.type | journalArticle | en |