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Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo
dc.creator | Ulukaya, E. | en |
dc.creator | Ari, F. | en |
dc.creator | Dimas, K. | en |
dc.creator | Ikitimur, E. I. | en |
dc.creator | Guney, E. | en |
dc.creator | Yilmaz, V. T. | en |
dc.date.accessioned | 2015-11-23T10:52:59Z | |
dc.date.available | 2015-11-23T10:52:59Z | |
dc.date.issued | 2011 | |
dc.identifier | 10.1016/j.ejmech.2011.07.055 | |
dc.identifier.issn | 0223-5234 | |
dc.identifier.uri | http://hdl.handle.net/11615/34197 | |
dc.description.abstract | Anti-cancer effects of a newly-synthesized palladium(II) complex, [Pd(sac)(terpy)](sac)center dot 4H(2)O (sac = saccharinate, and terpy = 2,2':6',2 ''-terpyridine), were tested against human breast cancer cell lines, MCF-7 and MDA-MB-231. The Pd complex had a strong anti-growth effect in a dose- and time-dependent manner in vitro. This effect was also confirmed by the experiment performed on Balb/c mice in vivo. The IC(50) values were 0.09 mu M for MDA-MB-231 and 3.05 mu M for MCF-7. It was also very effective in disrupting the formation of MDA-MB-231 tubules on matrigel, indicative of a putative anti-invasive activity. It induced apoptosis via the cell death genes of DR4 and DR5. In conclusion, this newly-synthesized Pd (II) complex represents a potentially active novel drug for the breast cancer treatment. (C) 2011 Elsevier Masson SAS. All rights reserved. | en |
dc.source | European Journal of Medicinal Chemistry | en |
dc.source.uri | <Go to ISI>://WOS:000296041600018 | |
dc.subject | Palladium(II) complex | en |
dc.subject | Breast cancer | en |
dc.subject | Cytotoxicity | en |
dc.subject | Apoptosis | en |
dc.subject | Treatment | en |
dc.subject | POTENTIAL ANTITUMOR AGENTS | en |
dc.subject | EHRLICH ASCITES TUMOR | en |
dc.subject | BIOLOGICAL | en |
dc.subject | EVALUATION | en |
dc.subject | PLATINUM(II) COMPLEXES | en |
dc.subject | CYTOTOXIC ACTIVITY | en |
dc.subject | PD(II) | en |
dc.subject | PT(II) | en |
dc.subject | ASSAY | en |
dc.subject | MICE | en |
dc.subject | MTT | en |
dc.subject | Chemistry, Medicinal | en |
dc.title | Anti-cancer activity of a novel palladium(II) complex on human breast cancer cells in vitro and in vivo | en |
dc.type | journalArticle | en |
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