| dc.creator | Tsitsimpikou, C. | en |
| dc.creator | Spyridaki, M. H. E. | en |
| dc.creator | Georgoulakis, I. | en |
| dc.creator | Kouretas, D. | en |
| dc.creator | Konstantinidou, M. | en |
| dc.creator | Georgakopoulos, C. G. | en |
| dc.date.accessioned | 2015-11-23T10:52:06Z | |
| dc.date.available | 2015-11-23T10:52:06Z | |
| dc.date.issued | 2001 | |
| dc.identifier | 10.1016/s0039-9140(01)00545-8 | |
| dc.identifier.issn | 0039-9140 | |
| dc.identifier.uri | http://hdl.handle.net/11615/34017 | |
| dc.description.abstract | Flurbiprofen and its main acidic metabolites were detected in equine urine after a single-dose administration of 500 mg flurbiprofen to two 2.5-3.5-years-old mares, in order to be used in equine doping control routine analysis. The urine levels of the parent drug were determined using GC/MS. Five acidic metabolites were found in the urine. The structure of the proposed metabolites was confirmed by FIRMS accurate mass measurements. The highest flurbiprofen concentration was 204 mug ml(-1) at 1-3 h post administration. Flurbiprofen could be detected for 24-37 h in urine using the standard screening procedure. All metabolites were present 25 h post administration, while 4'-hydroxyflurbiprofen could be traced for more than 48 h and it is regarded as the long-term metabolite of flurbiprofen in horse. (C) 2001 Elsevier Science B.V. All rights reserved. | en |
| dc.source.uri | <Go to ISI>://WOS:000173038600017 | |
| dc.subject | flurbiprofen | en |
| dc.subject | flurbiprofen metabolites | en |
| dc.subject | equine urine | en |
| dc.subject | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | en |
| dc.subject | PERFORMANCE LIQUID-CHROMATOGRAPHY | en |
| dc.subject | MASS-SPECTROMETRY | en |
| dc.subject | PHARMACOKINETICS | en |
| dc.subject | Chemistry, Analytical | en |
| dc.title | Elimination profiles of flurbiprofen and its metabolites in equine urine for doping analysis | en |
| dc.type | journalArticle | en |