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dc.creatorTsiamas, P.en
dc.creatorSeco, J.en
dc.creatorHan, Z.en
dc.creatorBhagwat, M.en
dc.creatorMaddox, J.en
dc.creatorKappas, C.en
dc.creatorTheodorou, K.en
dc.creatorMakrigiorgos, M.en
dc.creatorMarcus, K.en
dc.creatorZygmanski, P.en
dc.date.accessioned2015-11-23T10:51:19Z
dc.date.available2015-11-23T10:51:19Z
dc.date.issued2011
dc.identifier10.1118/1.3571419
dc.identifier.issn0094-2405
dc.identifier.urihttp://hdl.handle.net/11615/33879
dc.description.abstractPurpose: This study investigates the benefits of a modified flattening filter free (FFF) linac over the standard (STD) linac equipped with the flattening filter. Energy and angular spread of the electron beam of the FFF linac were modified. Modification of FFF beam parameters is explored to maximize the monitor unit efficiency and to minimize the head scatter in IMRT delivery for large target volumes or targets lying away from the central axis. Methods: The EGSnrc code is used to model FFF and STD linacs and study basic beam properties for both linac types in various beam configurations. Increasing energy of FFF linac results in similar beam attenuation properties and maximized dose rate compared to STD linac. Matching beam attenuation properties allows a more direct exploration of beam flatness of FFF linac in regard to IMRT delivery, especially away from the central axis where the effective dose rate is considerably smaller than the one at the central axis. Flatness of open beam dose profile of FFF linac is improved by increasing the angular spread of the electron beam. The resulting dose rate within the treatment field and outside of the field (peripheral dose) are characterized and compared to the unmodified FFF and STD linacs. Results: In order to match beam penetration properties, the energy of FFF is adjusted from 6.5 to 8.0 MeV for small to medium field sizes and from 6.5 to 8.5 MeV for larger ones. Dose rate of FFF vs STD linac increased by a factor of 1.9 (6.5 MeV) and 3.4-4.1 (8.0-8.5 MeV). Adjusting the mean angular spread of the electron beam from 0 degrees to 5 degrees-10 degrees resulted in complete flattening of photon beam for field sizes between 10 x 10 cm(2) and 15 x 15 cm(2) and partial flattening for field sizes from 15 x 15 cm(2) to 30 x 30 cm(2). Values of angular spread >= 14 degrees are not recommended as they exceed the opening of the primary collimator, affecting the area at the edges of the field. FFF fields of sizes smaller than 6 x 6 cm(2) are already flat and beam flattening is not necessary. Overall, the angular spread of 5 degrees-10 degrees is sufficient and can satisfactorily flatten open beam dose profiles even for larger field sizes. Increasing the electron beam angular spread amounts to a slight decrease of dose rate of FFF linac. However, for angular spread, 5 degrees-10 degrees dose rate factor of FFF vs STD is still about 1.6-2.6, depending on the field size (and the adjusted energy). Similarly, in case of peripheral dose, a moderate increase in dose can be observed for angular spread of 5 degrees-10 degrees and for field sizes 10 x 10 cm(2) to 30 x 30 cm(2). Lastly, beam flatness of not modified FFF linac can be conveniently described by an analytical function representing a ratio of STD vs FFF doses: 1 + b vertical bar r vertical bar(n). Conclusions: A modified FFF beamline with increased energy and electron beam angular spread results in satisfactory flattened beam and high dose rate within the field. Peripheral dose remaining at similar (or smaller) level than that of STD linac for the same delivered dose within the treatment field. (C) 2011 American Association of Physicists in Medicine. [DOI: 10.1118/1.3571419]en
dc.sourceMedical Physicsen
dc.source.uri<Go to ISI>://WOS:000290625700007
dc.subjectMonte Carloen
dc.subjectflattening filter freeen
dc.subjectelectron beam modificationen
dc.subjectperipheral doseen
dc.subjectIMRTen
dc.subjectMODULATED RADIATION-THERAPYen
dc.subjectFREE CLINICAL ACCELERATORen
dc.subjectMULTILEAFen
dc.subjectCOLLIMATOR TRANSMISSIONen
dc.subjectMEDICAL LINEAR-ACCELERATORen
dc.subjectDOSE CALCULATIONen
dc.subjectALGORITHMen
dc.subjectUNFLATTENED PHOTON BEAMSen
dc.subjectMONTE-CARLO-SIMULATIONen
dc.subjectSTOPPING-POWER RATIOSen
dc.subjectSTEREOTACTIC RADIOTHERAPYen
dc.subjectSPATIAL DEPENDENCEen
dc.subjectRadiology, Nuclear Medicine & Medical Imagingen
dc.titleA modification of flattening filter free linac for IMRTen
dc.typejournalArticleen


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